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Cat. No.: HY-168370

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YHS-12

YHS-12 is an ionizable cationic lipid, which can be used to synthesize lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA.

For research use only. We do not sell to patients.

CAS No.: 2959463-68-2
Formula: C₅₆H₁₁₂N₄O₂
Molecular Weight:873.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

YHS-12 Chemical Structure

CAS No.: 2959463-68-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

YHS-12 is an ionizable cationic lipid, which can be used to synthesize lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA^[1].

Chemical Information

CAS No. 2959463-68-2
Molecular Weight 873.51
Formula C₅₆H₁₁₂N₄O₂
SMILES

CCCCCCCCCCCCN(CCCCCCCCCCCC)CCNC(/C=C/C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang C, et al. mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model. ACS Nano. 2024 Jan 23;18(3):2261-2278. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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