Poloxamer L61
Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production.
For research use only. We do not sell to patients.
- CAS No.: 9003-11-6
- Molecular Weight:12600 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
The I-V characteristic curves of biomembranes prepared from Poloxamer L61 all exhibit nonlinearity at low voltages. When the voltage exceeds 50 mV, the conductivity of biomembranes prepared from Poloxamer L61 increases sharply, accompanied by a quantization phenomenon of jumping to a higher conductivity level, which may indicate the formation of new conductive channels on the membrane[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9003-11-6
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Molecular Weight 12600 (Average)
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SMILES
CC.[H(OCH2CH2)x(OCH2CH)y(OCH2CH2)zOH].[CH3]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sengupta A, et al. Poloxamer surfactant preserves cell viability during photoacoustic delivery of molecules into cells. Biotechnol Bioeng. 2015;112(2):405-415. [Content Brief]
[2]. Lemieux P, et al. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther. 2000;7(11):986-991. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poloxamer L61 Related Classifications
HY-D1005I Related Classifications
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- Poloxamer L61
- 9003-11-6
- Poloxamer L 61
- Poloxamer L-61
- Biochemical Assay Reagents
- laser-induced membrane permeabilization
- cancer cells
- cell membrane resealing
- cell viability
- plasmid DNA
- photoacoustic molecule delivery
- nonionic triblock copolymer surfactant
- extracellular matrix
- skeletal muscle
- USP-listed inactive excipient
- Inhibitor
- inhibitor
- inhibit