Poloxamer L61 

Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production^[1][2][3].

The I-V characteristic curves of biomembranes prepared from Poloxamer L61 all exhibit nonlinearity at low voltages. When the voltage exceeds 50 mV, the conductivity of biomembranes prepared from Poloxamer L61 increases sharply, accompanied by a quantization phenomenon of jumping to a higher conductivity level, which may indicate the formation of new conductive channels on the membrane^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12600 (Average)

9003-11-6

CC.[H(OCH2CH2)x(OCH2CH)y(OCH2CH2)zOH].[CH3]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sengupta A, et al. Poloxamer surfactant preserves cell viability during photoacoustic delivery of molecules into cells. Biotechnol Bioeng. 2015;112(2):405-415.

  [2]. Lemieux P, et al. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther. 2000;7(11):986-991.

  [3]. Anosov A A, et al. Different effects of two Poloxamers (L61 and F68) on the conductance of bilayer lipid membranes[J]. The European Physical Journal E, 2023, 46(3): 14.