1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine  (Synonyms: SLPC; 18:0-18:2 PC)

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (SLPC; 18:0-18:2 PC) is an endogenous phospholipid marker molecule in the glycerophospholipid metabolic pathway. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine is a core component of the phospholipid bilayer of biological membranes and a key responsive lipid for radiation injury and cardiometabolic diseases. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine constitutes the phospholipid bilayers of cell membranes and high-density lipoprotein (HDL), and regulates the core activity of lipoprotein functional homeostasis. The content of 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine in mouse serum shows a significant dose-dependent decrease with increasing ionizing radiation dose, and its level in human HDL also decreases significantly in metabolic syndrome. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can serve as a biological dosimeter marker for ionizing radiation injury, and is used for rapid and accurate assessment of radiation absorbed dose in exposed individuals. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can also act as a lipidomics research target for cardiometabolic diseases such as lipid metabolic syndrome and early-onset coronary heart disease^[1][2].

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (endogenous relative quantitative concentration in mouse serum; detected via ex vivo serum treatment at 6 h post ionizing radiation exposure) is identified as an ionizing radiation-responsive lipid in mouse serum lipidomics LC-MS assays. Its serum abundance decreases significantly with increasing doses of 0-8 Gy ⁶⁰Co source γ-ray irradiation, and shows a strong linear negative correlation with radiation dose ^[2].
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (endogenous relative quantitative concentration in mouse serum; detected via ex vivo serum treatment at 72 h after ionizing radiation exposure) shows a significant dose-dependent decrease in serum abundance with increasing irradiation doses of 0-8 Gy ⁶⁰Co source γ-rays in mouse serum lipidomics LC-MS assays, and exhibits a strong linear negative correlation with radiation dose^[2].
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine shows a 15% lower level in the HDL3 subfraction of subjects with metabolic syndrome compared to non-diseased subjects in human HDL lipidomics LC-MS detection experiments^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

786.11

C₄₄H₈₄NO₈P

27098-24-4

Liquid

Colorless to light yellow

CCCCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Paavola T, Bergmann U, Kuusisto S, et al. Distinct fatty acid compositions of hdl phospholipids are characteristic of metabolic syndrome and premature coronary heart disease—Family study[J]. International Journal of Molecular Sciences, 2021, 22(9): 4908.

  [2]. Huang J, Wang Q, Qi Z, et al. Lipidomic profiling for serum biomarkers in mice exposed to ionizing radiation[J]. Dose-Response, 2020, 18(2): 1559325820914209.