OF-Deg-Lin
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
For research use only. We do not sell to patients.
- CAS No.: 1853202-95-5
- Formula: C92H160N4O10
- Molecular Weight:1482.28
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Storage:
-20°C, sealed storage, away from moisture and light, under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
OF-Deg-Lin is an ionizable lipid material that forms lipid nanoparticles (LNPs) with components such as cholesterol, lipid-anchored polyethylene glycol (PEG), phospholipids and mRNA for in vivo delivery of mRNA. OF-Deg-Lin LNPs specifically delivers mRNA to the spleen, inducing protein expression in the spleen, while less protein expression in other organs such as the liver[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mouse models[2]
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Dosage:0.75-2.25 mg/kg in form of OF-Deg-Lin mRNA LNPs
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Administration:iv, single dose
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Result:Induced 85% of total protein production in the spleen, labeled ca. 7% of the total B cell population in C57BL/6 mice.
Chemical Information
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CAS No. 1853202-95-5
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Appearance Oil
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Molecular Weight 1482.28
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Formula C92H160N4O10
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(OCCN(CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCC1C(NC(C(N1)=O)CCCCN(CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light, under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (67.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rissanou AN, Karatasos K. Effects of the structure of lipid-based agents in their complexation with a single stranded mRNA fragment: a computational study. Soft Matter. 2022;18(33):6229-6245. [Content Brief]
[2]. Fenton OS, et al., Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes. Adv Mater. 2017 Sep;29(33). [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6746 mL | 3.3732 mL | 6.7464 mL | 16.8659 mL |
| 5 mM | 0.1349 mL | 0.6746 mL | 1.3493 mL | 3.3732 mL | |
| 10 mM | 0.0675 mL | 0.3373 mL | 0.6746 mL | 1.6866 mL | |
| 15 mM | 0.0450 mL | 0.2249 mL | 0.4498 mL | 1.1244 mL | |
| 20 mM | 0.0337 mL | 0.1687 mL | 0.3373 mL | 0.8433 mL | |
| 25 mM | 0.0270 mL | 0.1349 mL | 0.2699 mL | 0.6746 mL | |
| 30 mM | 0.0225 mL | 0.1124 mL | 0.2249 mL | 0.5622 mL | |
| 40 mM | 0.0169 mL | 0.0843 mL | 0.1687 mL | 0.4216 mL | |
| 50 mM | 0.0135 mL | 0.0675 mL | 0.1349 mL | 0.3373 mL | |
| 60 mM | 0.0112 mL | 0.0562 mL | 0.1124 mL | 0.2811 mL |
OF-Deg-Lin Related Classifications
HY-134782 Related Classifications
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