1,2-Dimyristoyl-sn-glycerol
Based on 1 Customer Validation
1,2-Dimyristoyl-sn-glycerol is a protein kinase C activator.1,2-Dimyristoyl-sn-glycerol activates PKC α.1,2-Dimyristoyl-sn-glycerol induces increased acetylcholinesterase (AChE) activity in Schistosoma mansoni.1,2-Dimyristoyl-sn-glycerol can be used for the research of schistosomiasis.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 60562-16-5
- Formula: C31H60O5
- Molecular Weight:512.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
PKCα |
AChE |
In Vitro
1,2-Dimyristoyl-sn-glycerol activates PKC α with a Ka of 0.5-4.1 μM[1].
1,2-Dimyristoyl-sn-glycerol (25 μg/mL; 2 h) increases total acetylcholinesterase activity by ~40% in 20 h post-transformation Schistosoma mansoni parasites[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 60562-16-5
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Appearance Solid
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Molecular Weight 512.81
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Formula C31H60O5
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Color White to off-white
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SMILES
OC[C@H](OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
Ethanol : 25 mg/mL (48.75 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Ethanol | 1 mM | 1.9500 mL | 9.7502 mL | 19.5004 mL | 48.7510 mL |
| 5 mM | 0.3900 mL | 1.9500 mL | 3.9001 mL | 9.7502 mL | |
| 10 mM | 0.1950 mL | 0.9750 mL | 1.9500 mL | 4.8751 mL | |
| 15 mM | 0.1300 mL | 0.6500 mL | 1.3000 mL | 3.2501 mL | |
| 20 mM | 0.0975 mL | 0.4875 mL | 0.9750 mL | 2.4375 mL | |
| 25 mM | 0.0780 mL | 0.3900 mL | 0.7800 mL | 1.9500 mL | |
| 30 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6250 mL | |
| 40 mM | 0.0488 mL | 0.2438 mL | 0.4875 mL | 1.2188 mL |
1,2-Dimyristoyl-sn-glycerol Related Classifications
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