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Bisindolylmaleimide I

(Synonyms: GF109203X; Go 6850)
44 Cited Publications
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Based on 44 publication(s) in Google Scholar

Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor.

For research use only. We do not sell to patients.

  • Purity: 98.15%
  • CAS No.: 133052-90-1
  • Formula: C25H24N4O2
  • Molecular Weight:412.48
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Bisindolylmaleimide I Chemical Structure
    Bisindolylmaleimide I Chemical Structure
  • Experimental Validation Results for Bisindolylmaleimide I
  • Experimental Validation Results for Bisindolylmaleimide I
  • Experimental Validation Results for Bisindolylmaleimide I
  • Experimental Validation Results for Bisindolylmaleimide I
  • Experimental Validation Results for Bisindolylmaleimide I
CAS No.: 133052-90-1
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  • Cell Proliferation/Viability Assay
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  • Bisindolylmaleimide I Chemical Structure
    Bisindolylmaleimide I Chemical Structure
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    Bisindolylmaleimide I purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Jul 1;20(7):2038-2052. [Abstract]

    Customer Validation
     Cell viability was measured by cell counting kit-8 in MN9D cells with/without MPP+ 0.5 mM and Bisindolylmaleimide I (BIM) 5 µM treatment for 24 hours.

  • 1/16

    Bisindolylmaleimide I purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Jul 1;20(7):2038-2052. [Abstract]

    Customer Validation
     C11-BODIPY fluorescence analysis suggested that MPP+ increased intracellular lipid peroxidation in MN9D cells, and that this effect was reversed by Bisindolylmaleimide I (BIM) (5 μM) treatment.

  • 1/16

    Bisindolylmaleimide I purchased from MedChemExpress. Usage Cited in: Mucosal Immunol. 2022 Feb;15(2):314-326. [Abstract]

    Customer Validation
     Lung ILC2s were treated with vehicle or UCB (50 μM) and /or Honokiol (5 μM) and /or Bisindolylmaleimide I (BIM1) (5 μM) in the presence of IL-2, IL-7 and IL-33 for 48 h. Flow cytometric analysis of p-ERK1/2 levels was performed.

  • 1/16

    Bisindolylmaleimide I purchased from MedChemExpress. Usage Cited in: Mucosal Immunol. 2022 Feb;15(2):314-326. [Abstract]

    Customer Validation
     The amounts of IL-5 and IL-13 in the supernatants were measured by ELISA.

  • 1/16

    Bisindolylmaleimide I purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 11;11(11):5279-5295. [Abstract]

    Customer Validation
     SH-SY5Y cells were simultaneously treated with C004019 (1 or 10 µM) and wortmainnin (WO, 1 µM) and Bisindolylmaleimide I (GF-109203X) (GFX, 1 µM) for 24 h to induce tau hyperphosphorylation, and then tau was measured by Western blotting.

  • Bisindolylmaleimide I