1,2-Dioleoyl-sn-glycerol
Based on 1 Customer Validation
1,2-Dioleoyl-sn-glycerol (sn-1,2-Dioleoylglycerol; 18:1/18:1-DG) is a glycerolipid located on the plasma membrane. 1,2-Dioleoyl-sn-glycerol consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. 1,2-Dioleoyl-sn-glycerol can induce acrosome reaction in human sperm .
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 24529-88-2
- Formula: C39H72O5
- Molecular Weight:620.99
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
1,2-Dioleoyl-sn-glycerol (50 μM) induces human sperm acrosome reaction with ED50 and delta AR max values of 33 μM and 24%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 24529-88-2
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Appearance Liquid (Density: 0.9218 g/cm3)
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Molecular Weight 620.99
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Formula C39H72O5
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Color Colorless to light yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(O[C@@H](CO)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
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Synonyms
sn-1,2-Dioleoylglycerol; 18:1/18:1-DG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (161.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 50 mg/mL (80.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (587 KB)
- English - EN (587 KB)
- Français - FR (587 KB)
- Deutsch - DE (587 KB)
- Norwegian - NO (587 KB)
- Español - ES (587 KB)
- Swedish - SV (587 KB)
- Italian - IT (587 KB)
- Korean - KR (587 KB)
- Portuguese - PT (587 KB)
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Handling Instructions (2659 KB)
References
[1]. Komenoi S, et al. Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol. FEBS Lett. 2015 May 8;589(11):1272-7. [Content Brief]
[2]. Doherty CM, et al. Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction. J Androl. 1995 Jan-Feb;16(1):36-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.6103 mL | 8.0517 mL | 16.1033 mL | 40.2583 mL |
| 5 mM | 0.3221 mL | 1.6103 mL | 3.2207 mL | 8.0517 mL | |
| 10 mM | 0.1610 mL | 0.8052 mL | 1.6103 mL | 4.0258 mL | |
| 15 mM | 0.1074 mL | 0.5368 mL | 1.0736 mL | 2.6839 mL | |
| 20 mM | 0.0805 mL | 0.4026 mL | 0.8052 mL | 2.0129 mL | |
| 25 mM | 0.0644 mL | 0.3221 mL | 0.6441 mL | 1.6103 mL | |
| 30 mM | 0.0537 mL | 0.2684 mL | 0.5368 mL | 1.3419 mL | |
| 40 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 1.0065 mL | |
| 50 mM | 0.0322 mL | 0.1610 mL | 0.3221 mL | 0.8052 mL | |
| 60 mM | 0.0268 mL | 0.1342 mL | 0.2684 mL | 0.6710 mL | |
| 80 mM | 0.0201 mL | 0.1006 mL | 0.2013 mL | 0.5032 mL | |
| DMSO | 100 mM | 0.0161 mL | 0.0805 mL | 0.1610 mL | 0.4026 mL |
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