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  4. 1,2-Dioleoyl-sn-glycerol

1,2-Dioleoyl-sn-glycerol  (Synonyms: sn-1,2-Dioleoylglycerol; 18:1/18:1-DG)

Cat. No.: HY-141572 Purity: 99.96%
COA
SDS
Handling Instructions Technical Support

1,2-Dioleoyl-sn-glycerol (sn-1,2-Dioleoylglycerol; 18:1/18:1-DG) is a glycerolipid located on the plasma membrane. 1,2-Dioleoyl-sn-glycerol consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. 1,2-Dioleoyl-sn-glycerol can induce acrosome reaction in human sperm .

For research use only. We do not sell to patients.

1,2-Dioleoyl-sn-glycerol

1,2-Dioleoyl-sn-glycerol Chemical Structure

CAS No. : 24529-88-2

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1,2-Dioleoyl-sn-glycerol Related Antibodies

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Description

1,2-Dioleoyl-sn-glycerol (sn-1,2-Dioleoylglycerol; 18:1/18:1-DG) is a glycerolipid located on the plasma membrane. 1,2-Dioleoyl-sn-glycerol consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. 1,2-Dioleoyl-sn-glycerol can induce acrosome reaction in human sperm [1][2].

In Vitro

1,2-Dioleoyl-sn-glycerol (50 μM) induces human sperm acrosome reaction with ED50 and delta AR max values of 33 μM and 24%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,2-Dioleoyl-sn-glycerol Related Antibodies
Molecular Weight

620.99

Formula

C39H72O5
CAS No.
Appearance

Liquid (Density: 0.9218 g/cm3)

Color

Colorless to light yellow

SMILES

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](CO)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (80.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6103 mL 8.0517 mL 16.1033 mL
5 mM 0.3221 mL 1.6103 mL 3.2207 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.96%

SDS (587 KB)

COA (237 KB) HNMR (265 KB) RP-HPLC (243 KB) MS (82 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.6103 mL 8.0517 mL 16.1033 mL 40.2583 mL
5 mM 0.3221 mL 1.6103 mL 3.2207 mL 8.0517 mL
10 mM 0.1610 mL 0.8052 mL 1.6103 mL 4.0258 mL
15 mM 0.1074 mL 0.5368 mL 1.0736 mL 2.6839 mL
20 mM 0.0805 mL 0.4026 mL 0.8052 mL 2.0129 mL
25 mM 0.0644 mL 0.3221 mL 0.6441 mL 1.6103 mL
30 mM 0.0537 mL 0.2684 mL 0.5368 mL 1.3419 mL
40 mM 0.0403 mL 0.2013 mL 0.4026 mL 1.0065 mL
50 mM 0.0322 mL 0.1610 mL 0.3221 mL 0.8052 mL
60 mM 0.0268 mL 0.1342 mL 0.2684 mL 0.6710 mL
80 mM 0.0201 mL 0.1006 mL 0.2013 mL 0.5032 mL
DMSO 100 mM 0.0161 mL 0.0805 mL 0.1610 mL 0.4026 mL
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1,2-Dioleoyl-sn-glycerol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2-Dioleoyl-sn-glycerol24529-88-2sn-1,2-Dioleoylglycerol 18:1/18:1-DGDrug DerivativeDrug derivativebiochemical assayreagentInhibitorinhibitorinhibit

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