1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine
Based on 1 Customer Validation
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) is a zwitterionic saturated phosphatidylethanolamine bearing two myristoyl (C14:0) chains, and serves as a model membrane component, a neutral lipid component of lipid nanoparticles, and a cocoa butter crystallization nucleating agent. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is used in nucleic acid delivery, construction of artificial cell membrane models, and research on urothelial carcinoma.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 998-07-2
- Formula: C33H66NO8P
- Molecular Weight:635.86
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-109541
Colfosceril miristate -
HY-22274
Sodium (R)-2,3-bis(tetradecanoyloxy)propyl (2,3-dihydroxypropyl) phosphate -
HY-W040268
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine -
HY-112005
DOPE -
HY-W040193
DSPC -
HY-112530
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine -
HY-W013078R
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (Standard) -
HY-113424A
1,2-Dioleoyl-sn-glycero-3-phosphocholine -
HY-W040268R
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (Standard) -
HY-W583868
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE -
HY-W040193GL
DSPC (GMP Like) -
HY-103660
18:0 LYSO-PE
Biological Activity
Description
In Vitro
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) (0.1 wt %) produces 70% dark chocolate with a Form V cocoa butter microcrystalline domain size of 96.76 nm and a microstrain of 2.82 ε, similar to properly tempered chocolate[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (0.79 mM; 12 h) reduces the paraffin-water interfacial tension to 20.19 mN/m, whereas the co-presence of POS increases the interfacial tension to 27.19 mN/m[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (approximately 4 mg; 5 min) exhibits three melting transitions at 106.78 °C, 137.58 °C, and 207.21 °C, and remains completely solid at typical chocolate processing temperatures[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (1:10 POS ratio; 1 h-3 days) strongly promotes POS crystallization (induction time of 25.9 min) and drives the rapid formation of a stable high-melting-point (3L) polymorph corresponding to Form V, with the high-melting-point fraction accounting for 94% at 1 h and reaching 100% at 18 h[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (0.1 wt %; 23-28 °C) significantly accelerates the crystallization of refined deodorized cocoa butter, with its Avrami rate constant at 28 °C being approximately 2 orders of magnitude higher than that of pure rbCB[2].
rbCB (0.1 wt %; 5 days) acts as a nucleating agent in refined cocoa butter, producing a high density of fine and uniform spherulites at 28 °C[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (0.1-15 mg/mL; 5-30 min) forms giant vesicles via the water-in-oil reverse emulsion method[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 998-07-2
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Appearance Solid
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Molecular Weight 635.86
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Formula C33H66NO8P
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCC)=O)=O
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Synonyms
DMPE
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Initial Source
Penicillium expansum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
Ethanol : 2 mg/mL (3.15 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Stobbs JA, et al. Dimyristoylphosphoethanolamine Addition During Chocolate Manufacture Promotes Proper Tempering under Simple Cooling Conditions without Shear. Crystal growth & design. 2025 Jun 18;25(12):4621-4635. [Content Brief]
[3]. Wang F, et al. Exploring the influence of phospholipid monolayer conformation and environmental conditions on the interfacial binding of Gibberella Zeae lipase. International journal of biological macromolecules. 2019 Jul 01;132:1051-1056. [Content Brief]
[4]. Xu B, et al. Giant Vesicles Produced with Phosphatidylcholines (PCs) and Phosphatidylethanolamines (PEs) by Water-in-Oil Inverted Emulsions. Life (Basel, Switzerland). 2021 Mar 10;11(3):223. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.5727 mL | 7.8634 mL | 15.7267 mL | 39.3168 mL |
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine Related Classifications
HY-W013078 Related Classifications
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Keywords
- 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine
- 998-07-2
- DMPE
- Biochemical Assay Reagents
- Langmuir monolayers
- phosphatidylethanolamine lipid
- cocoa butter crystallization
- urothelial cancer
- nucleic acid delivery
- Gibberella zeae lipase
- giant vesicles
- lipid nanoparticle
- siRNA formulations
- Form V polymorph
- Inhibitor
- inhibitor
- inhibit