Colfosceril miristate
Based on 2 publication(s) in Google Scholar
Colfosceril miristate (DMPC) is a synthetic phospholipid. Colfosceril miristate has antiproliferative effects on various tumors. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 18194-24-6
- Formula: C36H72NO8P
- Molecular Weight:677.93
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-109506
DPPC -
HY-113424A
1,2-Dioleoyl-sn-glycero-3-phosphocholine -
HY-W040193
DSPC -
HY-112005
DOPE -
HY-113217
Cholesteryl oleate -
HY-107737
1,2-DLPC -
HY-22274
Sodium (R)-2,3-bis(tetradecanoyloxy)propyl (2,3-dihydroxypropyl) phosphate -
HY-W251428
Phosphatidylglycerols (egg) sodium salt -
HY-N0322
Cholesterol (from animal) -
HY-130462
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC -
HY-112530
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine -
HY-112754A
DOTAP chloride
Publications Citing Use of MedChemExpress (MCE) Colfosceril miristate
More
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | IC50 |
293 μM
Compound: DMPC
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Growth inhibition of human MOLT4 cells after 5 days by MTT assay
Growth inhibition of human MOLT4 cells after 5 days by MTT assay
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[PMID: 18672367] |
| MOLT-4 | IC50 |
50 μM
Compound: DMPC
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Growth inhibition of HIV1 3B infected human MOLT4 cells after 5 days by MTT assay
Growth inhibition of HIV1 3B infected human MOLT4 cells after 5 days by MTT assay
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[PMID: 18672367] |
In Vitro
Colfosceril miristate (20 mM) stabilizes Carmofur at neutral pH (pH= 5-8)[2].
Colfosceril miristate (0.08-250 μM, 72 h) shows cytotoxicity on monolayer tumor cell lines SHSY-5Y, MDA-MB-435s and HT-1080, with IC50s of 214, 231 and 20 μM[2].
Colfosceril miristate (12 h) distinctly enhances the ability of nanoparticles to enter PC-12 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18194-24-6
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Appearance Solid
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Molecular Weight 677.93
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Formula C36H72NO8P
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
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Synonyms
DMPC; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine; Dimyristoyl phosphatidylcholine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
Ultrasound-triggered dissolving microneedle platform for cGAS-STING-mediated precision immunotherapy of melanoma. [Abstract]2026 Mar 2:37:102990. PMID: 41815866 -
Adv Healthc Mater
Lipoprotein-Based Nanocatalyst Enables Targeted Treatment of APAP-Induced Liver Injury via Enhanced Macropinocytosis. [Abstract]2025 Sep;14(25):e2500507. PMID: 40411876
Solvent & Solubility
In Vitro:
Ethanol : 50 mg/mL (73.75 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (7.38 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (7.38 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 5 mg/mL (7.38 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Iwona Budziak, et al. Effect of polyols on the DMPC lipid monolayers and bilayers. Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2166-2174. [Content Brief]
[2]. Domracheva I, et al. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect. Toxicol Rep. 2015 Jan 27;2:377-383. [Content Brief]
[3]. Han D, et al. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine promotes the adhesion of nanoparticles to bio-membranes and transport in rat brain. RSC Adv. 2021 Nov 3;11(56):35455-35462. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.4751 mL | 7.3754 mL | 14.7508 mL | 36.8770 mL |
| 5 mM | 0.2950 mL | 1.4751 mL | 2.9502 mL | 7.3754 mL | |
| 10 mM | 0.1475 mL | 0.7375 mL | 1.4751 mL | 3.6877 mL | |
| 15 mM | 0.0983 mL | 0.4917 mL | 0.9834 mL | 2.4585 mL | |
| 20 mM | 0.0738 mL | 0.3688 mL | 0.7375 mL | 1.8438 mL | |
| 25 mM | 0.0590 mL | 0.2950 mL | 0.5900 mL | 1.4751 mL | |
| 30 mM | 0.0492 mL | 0.2458 mL | 0.4917 mL | 1.2292 mL | |
| 40 mM | 0.0369 mL | 0.1844 mL | 0.3688 mL | 0.9219 mL | |
| 50 mM | 0.0295 mL | 0.1475 mL | 0.2950 mL | 0.7375 mL | |
| 60 mM | 0.0246 mL | 0.1229 mL | 0.2458 mL | 0.6146 mL |
Colfosceril miristate Related Classifications
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