2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Crefmirlimab

Crefmirlimab  (Synonyms: IAB22M2C; ImaginAb)

Cat. No.: HY-P99834 Purity: 97.616%
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Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., 89Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No. : 2611099-93-3

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Crefmirlimab Related Antibodies

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Description

Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., 89Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research[1].

Isotype

(scFv-kappa-heavy)-h-CH3
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

CD8A
In Vivo

89Zr-Df-Crefmirlimab (48-81 μCi; i.v.) enables non-invasive, dose- and time-dependent quantification of intratumoral CD8+ T cell recruitment in a human colorectal cancer adoptive transfer mouse model, with moderate correlation to immunohistochemical CD8+ T cell density (R2 up to 0.46)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-SCID IL-2Rγ null (NSG) (female)[1]
Dosage: 48-81 μCi (delivering ~50 μg)
Administration: i.v.
Result: Showed substantial uptake in CD8+ T cell-rich tissues (spleen and tumors) with minimal accumulation in background tissues (muscle, whole blood).
Detected dose-dependent increases in tumor uptake on day 9 post-bispecific antibody treatment, with a mean SUV of up to 1.54 (SEM) in the highest-dose bispecific antibody group.
Confirmed dose- and time-dependent tumor uptake via ex vivo gamma counting, with a mean tumor uptake of 13.0%ID/g (SEM) in the highest-dose bispecific antibody group on day 9.
Showed moderate correlation between tumor radiotracer uptake (SUV or %ID/g) and CD8+ T cell density via immunohistochemistry (R2 = 0.46 and R2 = 0.45, respectively) on day 9.
Achieved tumor-to-blood ratios >8 and tumor-to-muscle ratios >27 for the highest bispecific antibody dose on day 9.
Gene ID

925  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

79.946 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Crefmirlimab]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • (scFv-kappa-heavy)-h-CH3
Biological Activity
  • Immobilized CD8 alpha Protein, Human (HEK293, His, HY-P71662) can bind Crefmirlimab. The EC50 for this effect is 532.3 ng/mL.
Purity & Documentation
References
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Crefmirlimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crefmirlimab2611099-93-3IAB22M2C ImaginAbTransmembrane GlycoproteinCD8 antibodycancerInhibitorinhibitorinhibit

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