2. Metabolic Enzyme/Protease
  3. Liposome
  4. LNP Lipid-8

LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model.

For research use only. We do not sell to patients.

LNP Lipid-8 Chemical Structure

LNP Lipid-8 Chemical Structure

CAS No. : 2408140-60-1

Size Price Stock Quantity
5 mg USD 320 In-stock
10 mg USD 540 In-stock
25 mg USD 1080 In-stock
50 mg USD 1700 In-stock
100 mg USD 2780 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

LNP Lipid-8 Related Antibodies

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Description

LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model[1].

Molecular Weight

702.02

Formula

C42H71NO7
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCN(CC)CCCOC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(C[C@@]12CC3C[C@H](C[C@@H](C3)C2)C1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (142.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4245 mL 7.1223 mL 14.2446 mL
5 mM 0.2849 mL 1.4245 mL 2.8489 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (242 KB) HNMR (132 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4245 mL 7.1223 mL 14.2446 mL 35.6115 mL
5 mM 0.2849 mL 1.4245 mL 2.8489 mL 7.1223 mL
10 mM 0.1424 mL 0.7122 mL 1.4245 mL 3.5612 mL
15 mM 0.0950 mL 0.4748 mL 0.9496 mL 2.3741 mL
20 mM 0.0712 mL 0.3561 mL 0.7122 mL 1.7806 mL
25 mM 0.0570 mL 0.2849 mL 0.5698 mL 1.4245 mL
30 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1871 mL
40 mM 0.0356 mL 0.1781 mL 0.3561 mL 0.8903 mL
50 mM 0.0285 mL 0.1424 mL 0.2849 mL 0.7122 mL
60 mM 0.0237 mL 0.1187 mL 0.2374 mL 0.5935 mL
80 mM 0.0178 mL 0.0890 mL 0.1781 mL 0.4451 mL
100 mM 0.0142 mL 0.0712 mL 0.1424 mL 0.3561 mL
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LNP Lipid-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LNP Lipid-82408140-60-1LNP Lipid8LNP Lipid 8Liposomeionizable lipidlipid nanoparticlesLNPsiRNAGFP siRNAsiGFPgene silencingInhibitorinhibitorinhibit

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