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Cat. No.: HY-156936

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RCB-02-4-8

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RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice.

For research use only. We do not sell to patients.

Purity: 99.3%
CAS No.: 2941228-91-5
Formula: C₆₈H₁₂₀N₂O₁₀
Molecular Weight:1125.69

Storage:

Solution, -20°C, 2 years

RCB-02-4-8 Chemical Structure

CAS No.: 2941228-91-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice^[1].

In Vivo

RCB-02-4-8 (Compound RCB-2-4-8) (i.t.; single dose or three doses) is formulated into LNPs for delivery of mRNA encoding Cre recombinase (mCre) to the lungs of Ai9 tdTomato reporter mice, demonstrating as an efficient tool for gene editing[1].
RCB-02-4-8 (i.t.; single dose) is formulated into LNPs that contain a CRISPR-Cas9 mRNA (mCas9) and a loxP-targeting sgRNA to the lungs of Ai9 tdTomato reporter mice, demonstrating as an efficient tool for gene editing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2941228-91-5
Appearance Liquid
Molecular Weight 1125.69
Formula C₆₈H₁₂₀N₂O₁₀
Color Colorless to light yellow
SMILES

CCN(CC)CCN(CCC(OCCCCCCCC/C=C\CC(CCCCCC)OC(OCC#CCCCCCC)=O)=O)CCC(OCCCCCCCC/C=C\CC(CCCCCC)OC(OCC#CCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anderson DG, et al. Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications. United States, WO2023107648 A. 2023-06-15.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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