2. Inhibitory Antibodies
  3. KWAR 23

KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research.

For research use only. We do not sell to patients.

KWAR 23 Chemical Structure

KWAR 23 Chemical Structure

CAS No. : 2243227-60-1

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KWAR 23 Related Antibodies

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Description

KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research[1].

In Vitro

KWAR 23 (0-1 μM; 4 h) shows antitumor activity of human neutrophil and macrophage[1].
KWAR 23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KWAR 23 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human macrophages and lymphoma cells
Concentration: 0-1 μM
Incubation Time: 4 h
Result: Showed human macrophages and neutrophils killing tumor cells following treatment with KWAR23.
In Vivo

KWAR23 (intraperitoneal injection; 10 mg/kg; every other day; 21 d) exhibits effective antitumor activity in a human SIRPA knockin mouse model[1].
KWAR23 enhances neutrophil and macrophage antitumor activity in SRG Mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SIRPA knock-in mouse model injected with Burkitt’s lymphoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; every other day; 21 d
Result: Led to strong inhibition of tumor growth when combined with Rituximab.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[KWAR 23]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.80%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KWAR 232243227-60-1KWAR23KWAR-23Othersantitumor activitycancer immunotherapyhuman macrophageslymphoma cellInhibitorinhibitorinhibit

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