SIRPA - signal regulatory protein alpha Gene

Also Known as BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140885

About SIRPA

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,894,167-1,940,592 (from NCBI)

This gene has 4 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 60 phenotypes. Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several Other members of the SIRP family. These related genes are located in close proximity to each Other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

SIRPA Products (4)

mRNA	Protein	Name
NM_001040022.1	NP_001035111.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001040023.2	NP_001035112.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001330728.1	NP_001317657.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor
NM_080792.3	NP_542970.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell-cell adhesion mediator activity	IPI IPI: Inferred from physical interaction	11509594	GOA
enables protein antigen binding	IPI IPI: Inferred from physical interaction	24026300	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17070842	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to interleukin-12	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24026300	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	24511121	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	11509594	GOA
involved in regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	11509594	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	11509594	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24026300	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRPA Protein Structure

V-set

C1-set

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type substrate 1	CD172 antigen-like family member A

SIRPA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIRPA	P78324	CD47	Homo sapiens	Q08722	Anti Tag CoIP	33961781
Intra	SIRPA	P78324	CD47	Homo sapiens	Q08722	ELISA	17070842

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRPA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7405	SIRP alpha/CD172a Protein, Human (HEK293, His-Myc)	P78324-1 (E31-R370)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7406	SIRP alpha/CD172a Protein, Human (HEK293, Fc)	P78324-1 (E31-R370)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70484	SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, His)	CAA71403.1 (E31-N370)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72412	SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	P78324-1 (E31-R370)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74546	SIRP alpha/CD172a Protein, Human (G75A, HEK293, His)	P78324-1 (E31-R370, G75A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76068	SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, His)	AAH38510.1 (E31-R369, S44L, S50T, I52T, H54R, V57A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76069	SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, Fc)	AAH38510.1 (E31-R369, S44L, S50T, I52T, H54R, V57A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77843	SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi)	P78324-1 (E31-R370, E33G, L44S, T50S, T52I, R54H)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77844	SIRP alpha V4/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	P78324-1 (E31-R370, E33G, L44S, T50S, T52I, R54H)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77846	SIRP alpha V6/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	P78324-1 (E31-R370, S105P)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77836	SIRP alpha V2/CD172a Protein, Human (HEK293, His)	AAH26692.1 (E31-R369)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77837	SIRP alpha V2/CD172a Protein, Human (HEK293, Fc)	AAH26692.1 (E31-R369)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77840	SIRP alpha V2/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	AAH26692.1 (E31-R369)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77841	SIRP alpha V3 Protein, Human (H54L, HEK293, His-Avi)	AAH38510.1 (E31-R369, H54L)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77842	SIRP alpha V3 Protein, Human (Biotinylated, H54L, HEK293, His-Avi)	AAH38510.1 (E31-R369, H54L)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77845	SIRP alpha V6/CD172a Protein, Human (HEK293, His-Avi)	P78324-1 (E31-R370, S105P)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77847	SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His-Avi)	ATD50864.1 (E31-R369, S44L, S50T, I52T, H54R, V57A)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78211	SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi)	P78324-1 (E31-R370)	≥ 95%, as determined by Bis-Tris PAGE.

SIRPA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81616	SIRP alpha Antibody (YA1361)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Refractory Plasma Cell Neoplasm
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991693	Ipsoprubart	Inhibitor	97%	Phase 3
HY-P991016	Peluntamig		99.9%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12932	SIRPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17207	Sirpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23659	Sirpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990555	BI-765063	Inhibitor	97.89%	Unkown
HY-P990723	Timdarpacept	Inhibitor	99.95%	Unkown
HY-P992346	DS-1103a	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIRPA	MGD	MGI:108563
Rattus norvegicus	SIRPA	RGD	RGD:3449
Others	SIRPA	NCBI