2. Immunology/Inflammation
  3. CD47
  4. DS-1103a

DS-1103a is a humanized IgG4 monoclonal antibody targeting SIRPa/CD172a. DS-1103a inhibits the interaction between SIRPα and CD47. DS-1103a enhances antibody-dependent cellular phagocytosis of cancer cells. DS-1103a can be used for the research of solid tumors. The recommended isotype control is: Human IgG4 (S228P) kappa, (HY-P99003).

For research use only. We do not sell to patients.

DS-1103a

DS-1103a Chemical Structure

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DS-1103a Related Antibodies

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Description

DS-1103a is a humanized IgG4 monoclonal antibody targeting SIRPa/CD172a. DS-1103a inhibits the interaction between SIRPα and CD47. DS-1103a enhances antibody-dependent cellular phagocytosis of cancer cells. DS-1103a can be used for the research of solid tumors. The recommended isotype control is: Human IgG4 (S228P) kappa, (HY-P99003)[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

DS-1103a binds to recombinant human SIRPα V1, with an association rate constant kon of 8.08 × 105 M-1s-1 and a dissociation rate constant koff of 4.98 × 10-4 s-1[1].
DS-1103a (0.001-10 μg/mL; 1 h at 4°C) binds to CHO-K1 cells expressing human SIRPα V1, SIRPα V2, SIRPβ1 and SIRPγ in a concentration-dependent manner[1].
DS-1103a (0.001-10 μg/mL; pre-incubated prior to CD47-Fc addition) inhibits the interaction between CHO-K1 cells expressing human SIRPα V1/V2 and CD47 in a concentration-dependent manner[1].
DS-1103a (0.001-1000 nM; 1 h at 4°C) binds to human monocyte-derived M2-like macrophages in a concentration-dependent manner[1].
DS-1103a (4 h) significantly enhances Dato-DXd-induced antibody-dependent cellular phagocytosis of human lung cancer LK-2 cells by human monocyte-derived M2-like macrophages[1].
DS-1103a (4 h) significantly enhances T-DXd-induced antibody-dependent cellular phagocytosis (ADCP) of human breast cancer SK-BR-3 cells by human monocyte-derived M2-like macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DS-1103a Related Antibodies
Gene ID

140885  [NCBI]

Accession
Target

SIRPa/CD172a
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DS-1103a Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-1103aCD47Cluster of Differentiation 47MER6OA3SIRPγSIRPβ1solid tumorsSignal regulatory protein alphaSIRPα V1SIRPα V2CHO-K1 cellsSIRPαhuman cancer cellsInhibitorinhibitorinhibit

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