DS-1103a

DS-1103a binds to recombinant human SIRPα V1, with an association rate constant k_on of 8.08 × 10⁵ M^-1s^-1 and a dissociation rate constant k_off of 4.98 × 10^-4 s^-1[1].
DS-1103a (0.001-10 μg/mL; 1 h at 4°C) binds to CHO-K1 cells expressing human SIRPα V1, SIRPα V2, SIRPβ1 and SIRPγ in a concentration-dependent manner^[1].
DS-1103a (0.001-10 μg/mL; pre-incubated prior to CD47-Fc addition) inhibits the interaction between CHO-K1 cells expressing human SIRPα V1/V2 and CD47 in a concentration-dependent manner^[1].
DS-1103a (0.001-1000 nM; 1 h at 4°C) binds to human monocyte-derived M2-like macrophages in a concentration-dependent manner^[1].
DS-1103a (4 h) significantly enhances Dato-DXd-induced antibody-dependent cellular phagocytosis of human lung cancer LK-2 cells by human monocyte-derived M2-like macrophages^[1].
DS-1103a (4 h) significantly enhances T-DXd-induced antibody-dependent cellular phagocytosis (ADCP) of human breast cancer SK-BR-3 cells by human monocyte-derived M2-like macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.