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Cat. No.: HY-171948

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FO-35

FO-35 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNPs). FO-35 can be used to delivery mRNA to mouse muscle and nasal mucosa as well as ferret lungs.

For research use only. We do not sell to patients.

Formula: C₆₅H₁₁₃N₃O₈
Molecular Weight:1064.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

FO-35 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

FO-35 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNPs). FO-35 can be used to delivery mRNA to mouse muscle and nasal mucosa as well as ferret lungs^[1].

Chemical Information

Molecular Weight 1064.61
Formula C₆₅H₁₁₃N₃O₈
SMILES

O=C(N(C(CCCC(OCC1=CCC(CC1)C(C)=C)=O)(C(NCCCC)=O)CCCC(OCC2=CCC(CC2)C(C)=C)=O)CCCCN(CC)CC)CCCCC(OC(CCCCCCCC)CCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Witten, J., et al., (2024). Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy. Nature biotechnology. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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