2. Metabolic Enzyme/Protease
  3. Liposome Ser/Thr Protease
  4. ssPalmE-P4-C2

ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research.

For research use only. We do not sell to patients.

ssPalmE-P4-C2

ssPalmE-P4-C2 Chemical Structure

CAS No. : 2247153-41-7

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Based on 1 publication(s) in Google Scholar

ssPalmE-P4-C2 Related Antibodies

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Description

ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research[1].

Molecular Weight

1402.15

Formula

C84H140N2O10S2
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(CCC(OCCC1CCN(CC1)CCSSCCN2CCC(CC2)CCOC(CCC(OC3=C(C)C4=C(OC(CC4)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C3C)=O)=O)=O)OC5=C(C)C6=C(OC(CC6)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (28.53 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7132 mL 3.5660 mL 7.1319 mL
5 mM 0.1426 mL 0.7132 mL 1.4264 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7132 mL 3.5660 mL 7.1319 mL 17.8298 mL
5 mM 0.1426 mL 0.7132 mL 1.4264 mL 3.5660 mL
10 mM 0.0713 mL 0.3566 mL 0.7132 mL 1.7830 mL
15 mM 0.0475 mL 0.2377 mL 0.4755 mL 1.1887 mL
20 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.8915 mL
25 mM 0.0285 mL 0.1426 mL 0.2853 mL 0.7132 mL
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ssPalmE-P4-C2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ssPalmE-P4-C22247153-41-7LiposomeSer/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesssPalmVitamin E?scaffoldGene knockdown activityLipid nanoparticlesLNPssiRNADyslipidemiahepatitis B/C infectionsTransthyretin amyloidosisInhibitorinhibitorinhibit

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