2. Peptides
  3. Peptide and Derivatives
  4. Peptides for Drug Delivery
  5. Targeting Peptides
  6. SDSSD

SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SDSSD

SDSSD Chemical Structure

CAS No. : 1927877-75-5

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SDSSD Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts[1][2].

In Vitro

SDSSD colocalizes with periostin in murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD reduces the subsequent binding of FITC-labeled SDSSD peptide to periostin in mouse MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD−PU efficiently delivers FAM-labeled siRNA to murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts, and the uptake process depends on periostin binding[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDSSD Related Antibodies
In Vivo

SDSSD-modified polyurethane nanomicelles delivering anti-miR-214 (10 mg/kg; tail vein injection; every 1 week; 1 month) reduce osteoblast miR-214 levels by 80% and significantly increase bone mineral density, mineral apposition rate, and bone mass in ovariectomized mice with osteoporosis[2].
SDSSD-modified polyurethane nanomicelles delivering GFP siRNA (10 mg/kg; tail vein injection) selectively reduce GFP mRNA and protein levels in bone tissue and isolated osteoblasts of GFP transgenic mice, demonstrating targeted gene knockdown efficacy[2].
SDSSD-modified polyurethane nanomicelles (10 mg/kg; tail vein injection) selectively deliver siRNA to bone tissues and mature osteoblasts in healthy mice, with no detectable in vivo toxicity or inflammatory response[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

509.42

Formula

C17H27N5O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Asp-Ser-Ser-Asp
Sequence Shortening

SDSSD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9630 mL 9.8151 mL 19.6302 mL
5 mM 0.3926 mL 1.9630 mL 3.9260 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9630 mL 9.8151 mL 19.6302 mL 49.0754 mL
5 mM 0.3926 mL 1.9630 mL 3.9260 mL 9.8151 mL
10 mM 0.1963 mL 0.9815 mL 1.9630 mL 4.9075 mL
15 mM 0.1309 mL 0.6543 mL 1.3087 mL 3.2717 mL
20 mM 0.0982 mL 0.4908 mL 0.9815 mL 2.4538 mL
25 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
30 mM 0.0654 mL 0.3272 mL 0.6543 mL 1.6358 mL
40 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2269 mL
50 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
60 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8179 mL
80 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6134 mL
100 mM 0.0196 mL 0.0982 mL 0.1963 mL 0.4908 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SDSSD Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDSSD1927877-75-5Othersosteoporosisperiostincalcium phosphate nanocompositessiRNAhuman hFOB 1.19 osteoblastsosteoblastsmouse MC3T3-E1 clone 4 osteoblastsmicroRNAovariectomized micepolyurethane nanomicellesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SDSSD
Cat. No.:
HY-P11070
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.