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  6. SDSSD

SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.

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カスタムペプチド

SDSSD

SDSSD 構造式

CAS 番号 : 1927877-75-5

容量 価格（税別） 在庫状況 数量
5 mg $60 在庫あり
10 mg $100 在庫あり
25 mg $160 在庫あり
50 mg $250 在庫あり
100 mg $375 在庫あり
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500 mg   お問い合わせ  

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SDSSD 関連抗体

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製品説明

SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts[1][2].

体外実験

SDSSD colocalizes with periostin in murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD reduces the subsequent binding of FITC-labeled SDSSD peptide to periostin in mouse MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD−PU efficiently delivers FAM-labeled siRNA to murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts, and the uptake process depends on periostin binding[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDSSD 関連抗体
体内実験

SDSSD-modified polyurethane nanomicelles delivering anti-miR-214 (10 mg/kg; tail vein injection; every 1 week; 1 month) reduce osteoblast miR-214 levels by 80% and significantly increase bone mineral density, mineral apposition rate, and bone mass in ovariectomized mice with osteoporosis[2].
SDSSD-modified polyurethane nanomicelles delivering GFP siRNA (10 mg/kg; tail vein injection) selectively reduce GFP mRNA and protein levels in bone tissue and isolated osteoblasts of GFP transgenic mice, demonstrating targeted gene knockdown efficacy[2].
SDSSD-modified polyurethane nanomicelles (10 mg/kg; tail vein injection) selectively deliver siRNA to bone tissues and mature osteoblasts in healthy mice, with no detectable in vivo toxicity or inflammatory response[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

509.42

分子式

C17H27N5O13
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Ser-Asp-Ser-Ser-Asp
Sequence Shortening

SDSSD
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (196.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9630 mL 9.8151 mL 19.6302 mL
5 mM 0.3926 mL 1.9630 mL 3.9260 mL
10 mM 0.1963 mL 0.9815 mL 1.9630 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9630 mL 9.8151 mL 19.6302 mL 49.0754 mL
5 mM 0.3926 mL 1.9630 mL 3.9260 mL 9.8151 mL
10 mM 0.1963 mL 0.9815 mL 1.9630 mL 4.9075 mL
15 mM 0.1309 mL 0.6543 mL 1.3087 mL 3.2717 mL
20 mM 0.0982 mL 0.4908 mL 0.9815 mL 2.4538 mL
25 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
30 mM 0.0654 mL 0.3272 mL 0.6543 mL 1.6358 mL
40 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2269 mL
50 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
60 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8179 mL
80 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6134 mL
100 mM 0.0196 mL 0.0982 mL 0.1963 mL 0.4908 mL
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SDSSD Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDSSD1927877-75-5Othersosteoporosisperiostincalcium phosphate nanocompositessiRNAhuman hFOB 1.19 osteoblastsosteoblastsmouse MC3T3-E1 clone 4 osteoblastsmicroRNAovariectomized micepolyurethane nanomicellesInhibitorinhibitorinhibit

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製品番号:
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