1927877-75-5
Chemical Structure
SDSSD
- CAS No.: 1927877-75-5
- Formula:C17H27N5O13
- Molecular Weight:509.42
InChIKey: RMXUISNRDFDCFN-WYCDGMCDSA-N
SMILES: O=C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)[C@H](CO)N
Biological Activity: SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts[1][2].
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SDSSD | 99.60% | SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts. | ||||||||||||||||||||
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- [1]. Pan Z, et al. Periostin-targeted SDSSD peptide decorated calcium phosphate nanocomposites incorporation with simvastatin for osteoporosis treatment. Nanotechnology. 2023;35(7):10.1088/1361-6528/ad0dc9. Published 2023 Dec 1. [Content Brief]
- [2]. Sun Y, et al. Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery. ACS Nano. 2016;10(6):5759-5768. [Content Brief]
Keywords
