Fipexide hydrochloride

Name: Fipexide hydrochloride
Brand: MedChemExpress
SKU: HY-B1124A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1124A Purity: 99.84%: Data Sheet
COA

SDS
Handling Instructions
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Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research. Fipexide hydrochloride acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.

For research use only. We do not sell to patients.

Fipexide hydrochloride Chemical Structure

CAS No. : 34161-23-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fipexide hydrochloride:

Fipexide In-stock
Fipexide hydrochloride (Standard) Get quote

1 Publications Citing Use of MCE Fipexide hydrochloride

•Int J Mol Med. 2019 Oct 31;20(21):5448. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Fipexide (50 μM; for 15 days) hydrochloride shows simple structures, which contained epidermal regions with well-expanded cells and actively dividing regions for Arabidopsis wild-type seedlings^[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fipexide (10 mg/kg; orally; 5-10 days) hydrochloride completely abolishes the memory deficit produced by kindling in rats^[3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Kindled rats^[3]
Dosage:	10 mg/kg
Administration:	Orally; 5-10 days
Result:	Completely abolishes the memory deficit produced by kindling. Antagonized the amnestic effect of Pentylenetetrazole (PTZ) -kindling.

Molecular Weight

425.31

Formula

C₂₀H₂₂Cl₂N₂O₄

CAS No.

34161-23-4

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(OCC(N2CCN(CC3=CC=C(OCO4)C4=C3)CC2)=O)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (117.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3512 mL	11.7561 mL	23.5123 mL
5 mM	0.4702 mL	2.3512 mL	4.7025 mL
10 mM	0.2351 mL	1.1756 mL	2.3512 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2 mg/mL (4.70 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2 mg/mL (4.70 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (245 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. A Marino, et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87. [Content Brief]

[2]. Takeshi Nakano, et al.FPX is a Novel Chemical Inducer that Promotes Callus Formation and Shoot Regeneration in Plants. Plant Cell Physiol. 2018 Aug 1;59(8):1555-1567. [Content Brief]

[3]. M G Genkova-Papazova, et al. Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats. Eur Neuropsychopharmacol. 1996 Nov;6(4):285-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3512 mL	11.7561 mL	23.5123 mL	58.7807 mL
	5 mM	0.4702 mL	2.3512 mL	4.7025 mL	11.7561 mL
	10 mM	0.2351 mL	1.1756 mL	2.3512 mL	5.8781 mL
	15 mM	0.1567 mL	0.7837 mL	1.5675 mL	3.9187 mL
	20 mM	0.1176 mL	0.5878 mL	1.1756 mL	2.9390 mL
	25 mM	0.0940 mL	0.4702 mL	0.9405 mL	2.3512 mL
	30 mM	0.0784 mL	0.3919 mL	0.7837 mL	1.9594 mL
	40 mM	0.0588 mL	0.2939 mL	0.5878 mL	1.4695 mL
	50 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1756 mL
	60 mM	0.0392 mL	0.1959 mL	0.3919 mL	0.9797 mL
	80 mM	0.0294 mL	0.1470 mL	0.2939 mL	0.7348 mL
	100 mM	0.0235 mL	0.1176 mL	0.2351 mL	0.5878 mL