1. Neuronal Signaling
  2. Dopamine Transporter

Dopamine Transporter

Dopamine Transporter (DAT) is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. Dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. Many diseases such as depression, bipolar disorder, Parkinson’s disease, and attention deficit hyperactivity disorder are associated with abnormal DA levels, implicating DAT as a factor in their etiology. Medications used to treat these disorders and many addictive drugs target DAT and enhance dopaminergic signaling by suppressing transmitter reuptake. DAT is regulated by multiple signaling systems, with PKC and ERK being two of the most well-characterized.

Dopamine Transporter Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-13217
    Vanoxerine dihydrochloride Inhibitor 99.64%
    Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).
  • HY-12242
    GBR 12935 dihydrochloride Inhibitor 98.90%
    GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor.
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
  • HY-B0403A
    Bupropion hydrochloride Inhibitor 99.06%
    Bupropion Hydrochloride is a unicyclic, aminoketone antidepressant.
  • HY-18610
    Diclofensine hydrochloride Inhibitor
    Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
  • HY-101631
    Levophacetoperane hydrochloride Inhibitor
    Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.
  • HY-13217A
    Vanoxerine Inhibitor
    Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).
  • HY-B1124
    Fipexide Inhibitor 99.87%
    Fipexide is a psychoactive drug of the piperazine chemical class, used as a nootropic drug, mainly for the treatment of senile dementia.
  • HY-18610A
    Diclofensine Inhibitor
    Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
  • HY-101612
    SPD-473 citrate Inhibitor
    SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.
  • HY-16044
    Amineptine Inhibitor 99.13%
    Amineptine(Survector) is a tricyclic antidepressant drug selectively blocking dopamine uptake, on 3H-imipramine binding, which was investigated in platelets of major depressed patients in conjunction with changes in clinical state.
  • HY-12242A
    GBR 12935 Inhibitor
    GBR 12935 is a potent, and selective dopamine reuptake inhibitor.