1. Neuronal Signaling
  2. Serotonin Transporter
    Dopamine Transporter
  3. Dasotraline hydrochloride

Dasotraline hydrochloride (Synonyms: SEP-225289 hydrochloride)

Cat. No.: HY-12850A Purity: 99.60%
Handling Instructions

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

For research use only. We do not sell to patients.

Dasotraline hydrochloride Chemical Structure

Dasotraline hydrochloride Chemical Structure

CAS No. : 675126-08-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 268 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 370 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Description

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

IC50 & Target

IC50: 4 nM (dopamine), 6 nM (norepinephrine), 11 nM (serotonin)[1]

In Vivo

Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (94.32 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0427 mL 15.2133 mL 30.4266 mL
5 mM 0.6085 mL 3.0427 mL 6.0853 mL
10 mM 0.3043 mL 1.5213 mL 3.0427 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

328.66

Formula

C₁₆H₁₆Cl₃N

CAS No.

675126-08-6

SMILES

N[[email protected]@H]1CC[[email protected]@H](C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C31.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Dasotraline hydrochloride
Cat. No.:
HY-12850A
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Dasotraline hydrochloride

Cat. No.: HY-12850A