Indatraline hydrochloride
Based on 1 Customer Validation
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 96850-13-4
- Formula: C16H16Cl3N
- Molecular Weight:328.66
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
monoamine transporter[1]
Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3[1].
Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm[1].
Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50 of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa cells
-
Concentration:0~5 μM
-
Incubation Time:24 hours
-
Result:Made the concentration-dependent conversion of LC3.
-
Cell Line:EGFP-LC3 stable cells
-
Concentration:1~10 μM
-
Incubation Time:24 hours
-
Result:EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 96850-13-4
-
Appearance Solid
-
Molecular Weight 328.66
-
Formula C16H16Cl3N
-
Color White to off-white
-
SMILES
CN[C@@H]1C[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl
-
Synonyms
Lu 19-005
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indatraline hydrochloride Related Classifications
HY-110019 Related Classifications
Powered by Bioz