2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor Dopamine Transporter
  4. BMS-466442

BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research.

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BMS-466442 Chemical Structure

BMS-466442 Chemical Structure

CAS No. : 1598424-76-0

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Based on 1 publication(s) in Google Scholar

BMS-466442 Related Antibodies

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Description

BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2].

IC50 & Target

α adrenergic receptor

≥10 μM (IC50)

ASCT1

1 nM (IC50)

In Vitro

BMS-466442 dose-dependently inhibits asc-1 activity in human asc-1 expressing cells and primary cultures with IC50 values of 36.8 ± 11.6 nM and 19.7 ± 6.7 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-466442 Related Antibodies
Molecular Weight

538.59

Formula

C31H30N4O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C3=CC4=C(C=C(C(OC)=C4)OCC5=CC=CC=C5)N3)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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BMS-466442 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-4664421598424-76-0BMS466442BMS 466442Adrenergic ReceptorDopamine TransporterBeta ReceptorDATSLC6A3HEK h-asc-1 cellsHEKtransporterSLC7A10asc1mutagenesisschizophreniaInhibitorinhibitorinhibit

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