1598424-76-0
1598424-76-0
Chemical Structure
BMS-466442
- CAS No.: 1598424-76-0
- Formula:C31H30N4O5
- Molecular Weight:538.59
IUPAC Name: methyl Nt-benzyl-Na-(6-(benzyloxy)-5-methoxy-1H-indole-2-carbonyl)-L-histidinate
InChIKey: UUCAHZCMRZOTNF-MHZLTWQESA-N
SMILES: O=C([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C3=CC4=C(C=C(C(OC)=C4)OCC5=CC=CC=C5)N3)=O)OC
Biological Activity: BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-466442 | 98.24% | BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research. | ||||||||||||||||||||
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References
- [1]. Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J Neurochem. 2014 Apr;129(2):275-83. [Content Brief]
- [2]. Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10(5):2510-2517. [Content Brief]
Keywords
