1. Neuronal Signaling
  2. Dopamine Transporter
  3. Diclofensine hydrochloride

Diclofensine hydrochloride (Synonyms: Ro 8-4650 hydrochloride)

Cat. No.: HY-18610 Purity: 96.44%
Handling Instructions

Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.

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Diclofensine hydrochloride Chemical Structure

Diclofensine hydrochloride Chemical Structure

CAS No. : 34041-84-4

Size Price Stock Quantity
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 372 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Diclofensine hydrochloride:

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Description

Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. IC50 value: Target: Dopamine reuptake inhibitor The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake [2]. Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release [3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 52 mg/mL (144.97 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7879 mL 13.9396 mL 27.8792 mL
5 mM 0.5576 mL 2.7879 mL 5.5758 mL
10 mM 0.2788 mL 1.3940 mL 2.7879 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

358.69

Formula

C₁₇H₁₈Cl₃NO

CAS No.

34041-84-4

SMILES

CN1CC2=C(C=CC(OC)=C2)C(C3=CC=C(Cl)C(Cl)=C3)C1.[H]Cl

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Room temperature in continental US; may vary elsewhere

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Product Name:
Diclofensine hydrochloride
Cat. No.:
HY-18610
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Diclofensine hydrochloride

Cat. No.: HY-18610