2. AHN 1-055 hydrochloride

AHN 1-055 hydrochloride  (Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride)

Cat. No.: HY-101315 Purity: 99.82%
COA Handling Instructions

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AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT).

For research use only. We do not sell to patients.

AHN 1-055 hydrochloride Chemical Structure

AHN 1-055 hydrochloride Chemical Structure

CAS No. : 202646-03-5

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 72 In-stock
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Based on 1 publication(s) in Google Scholar

AHN 1-055 hydrochloride Related Antibodies

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Description

AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT)[1].

IC50 & Target

IC50: 71 nM (dopamine uptake)[1]
In Vivo

AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC50 of 311.8 ng/ml in vivo[1].
AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (250-275 g)[1]
Dosage: 5 mg/kg (Pharmacokinetic Analysis)
Administration: I.v. administration
Result: Cmax (1.48 mg/L); T1/2 (7.69 h).
Molecular Weight

379.87

Formula

C21H24ClF2NO
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (263.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 33.33 mg/mL (87.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6325 mL 13.1624 mL 26.3248 mL
5 mM 0.5265 mL 2.6325 mL 5.2650 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.82%

COA (254 KB) HNMR (278 KB) RP-HPLC (237 KB) MS (68 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6325 mL 13.1624 mL 26.3248 mL 65.8120 mL
5 mM 0.5265 mL 2.6325 mL 5.2650 mL 13.1624 mL
10 mM 0.2632 mL 1.3162 mL 2.6325 mL 6.5812 mL
15 mM 0.1755 mL 0.8775 mL 1.7550 mL 4.3875 mL
20 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2906 mL
25 mM 0.1053 mL 0.5265 mL 1.0530 mL 2.6325 mL
30 mM 0.0877 mL 0.4387 mL 0.8775 mL 2.1937 mL
40 mM 0.0658 mL 0.3291 mL 0.6581 mL 1.6453 mL
50 mM 0.0526 mL 0.2632 mL 0.5265 mL 1.3162 mL
60 mM 0.0439 mL 0.2194 mL 0.4387 mL 1.0969 mL
80 mM 0.0329 mL 0.1645 mL 0.3291 mL 0.8226 mL
DMSO 100 mM 0.0263 mL 0.1316 mL 0.2632 mL 0.6581 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AHN 1-055202646-03-53α-Bis-(4-fluorophenyl) MethoxytropaneInhibitorinhibitorinhibit

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