1. Neuronal Signaling
  2. Dopamine Transporter
  3. AHN 1-055 hydrochloride

AHN 1-055 hydrochloride (Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride)

Cat. No.: HY-101315
Handling Instructions

AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse.

For research use only. We do not sell to patients.

AHN 1-055 hydrochloride Chemical Structure

AHN 1-055 hydrochloride Chemical Structure

CAS No. : 202646-03-5

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Description

AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse[1].

IC50 & Target

IC50: 71 nM (dopamine uptake)[1]

In Vivo

AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC50 of 311.8 ng/ml in vivo[1].
AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].

Animal Model: Adult male Sprague Dawley rats (250-275 g)[1]
Dosage: 5 mg/kg (Pharmacokinetic Analysis)
Administration: I.v. administration
Result: Cmax (1.48 mg/L); T1/2 (7.69 h).
Molecular Weight

379.87

Formula

C₂₁H₂₄ClF₂NO

CAS No.

202646-03-5

SMILES

CN1[[email protected]@H]2C[[email protected]@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[[email protected]]1CC2.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AHN 1-0553α-Bis-(4-fluorophenyl) MethoxytropaneDopamine TransporterDATSLC6A3DopamineuptaketransportercocaineInhibitorinhibitorinhibit

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AHN 1-055 hydrochloride
Cat. No.:
HY-101315
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