AHN 1-055 hydrochloride
Based on 3 publication(s) in Google Scholar
AHN 1-055 hydrochloride is a dopamine uptake inhibitor that can cross the blood-brain barrier, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT).
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- Purity : 99.96%
- CAS No.: 202646-03-5
- 화학식: C21H24ClF2NO
- 분자량:379.87
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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HY-101315R
AHN 1-055 hydrochloride (Standard)Dopamine Uptake Inhibitor -
HY-18610
Diclofensine hydrochlorideNeuronal Monoamine Uptake Inhibitor -
HY-101612
SPD-473 citrateSerotonin/Dopamine/Norepinephrine Reuptake Inhibitior -
HY-18610R
Diclofensine hydrochloride (Standard)Standard of Diclofensine hydrochloride
Publications Citing Use of MedChemExpress (MCE) AHN 1-055 hydrochloride
More
Biological Activity
제품 설명
IC50 & Target
IC50: 71 nM (dopamine uptake)[1]
In Vivo
AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague Dawley rats (250-275 g)[1]
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Dosage:5 mg/kg (Pharmacokinetic Analysis)
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Administration:I.v. administration
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Result:Cmax (1.48 mg/L); T1/2 (7.69 h).
Chemical Information
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CAS No. 202646-03-5
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Appearance Solid
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분자량 379.87
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화학식 C21H24ClF2NO
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Color White to yellow
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SMILES
CN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.Cl
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Synonyms
3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Ecotoxicol Environ Saf
T-2 toxin triggers depression-like behaviors via upregulation of dopamine transporter in nucleus accumbens of male mice. [Abstract]2025 Jan 1:289:117392. PMID: 39616663 -
Arch Pharm (Weinheim)
2023 Jan;356(1):e2200371. PMID: 36316225 -
용액&용해도
In Vitro:
DMSO : 100 mg/mL (263.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 33.33 mg/mL (87.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sangeeta R, et, al. Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis. Biopharm Drug Dispos. 2006 Jul; 27(5): 229-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.6325 mL | 13.1624 mL | 26.3248 mL | 65.8120 mL |
| 5 mM | 0.5265 mL | 2.6325 mL | 5.2650 mL | 13.1624 mL | |
| 10 mM | 0.2632 mL | 1.3162 mL | 2.6325 mL | 6.5812 mL | |
| 15 mM | 0.1755 mL | 0.8775 mL | 1.7550 mL | 4.3875 mL | |
| 20 mM | 0.1316 mL | 0.6581 mL | 1.3162 mL | 3.2906 mL | |
| 25 mM | 0.1053 mL | 0.5265 mL | 1.0530 mL | 2.6325 mL | |
| 30 mM | 0.0877 mL | 0.4387 mL | 0.8775 mL | 2.1937 mL | |
| 40 mM | 0.0658 mL | 0.3291 mL | 0.6581 mL | 1.6453 mL | |
| 50 mM | 0.0526 mL | 0.2632 mL | 0.5265 mL | 1.3162 mL | |
| 60 mM | 0.0439 mL | 0.2194 mL | 0.4387 mL | 1.0969 mL | |
| 80 mM | 0.0329 mL | 0.1645 mL | 0.3291 mL | 0.8226 mL | |
| DMSO | 100 mM | 0.0263 mL | 0.1316 mL | 0.2632 mL | 0.6581 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AHN 1-055 hydrochloride Related Classifications
HY-101315 Related Classifications
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