1. Neuronal Signaling
  2. Dopamine Transporter
  3. AHN 1-055 hydrochloride

AHN 1-055 hydrochloride (Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride)

Cat. No.: HY-101315
Handling Instructions

AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse.

For research use only. We do not sell to patients.

AHN 1-055 hydrochloride Chemical Structure

AHN 1-055 hydrochloride Chemical Structure

CAS No. : 202646-03-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
5 mg USD 65 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse[1].

IC50 & Target

IC50: 71 nM (dopamine uptake)[1]

In Vivo

AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC50 of 311.8 ng/ml in vivo[1].
AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (250-275 g)[1]
Dosage: 5 mg/kg (Pharmacokinetic Analysis)
Administration: I.v. administration
Result: Cmax (1.48 mg/L); T1/2 (7.69 h).
Molecular Weight

379.87

Formula

C₂₁H₂₄ClF₂NO

CAS No.

202646-03-5

SMILES

CN1[[email protected]@H]2C[[email protected]@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[[email protected]]1CC2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (329.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6325 mL 13.1624 mL 26.3248 mL
5 mM 0.5265 mL 2.6325 mL 5.2650 mL
10 mM 0.2632 mL 1.3162 mL 2.6325 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AHN 1-0553α-Bis-(4-fluorophenyl) MethoxytropaneDopamine TransporterDATSLC6A3DopamineuptaketransportercocaineInhibitorinhibitorinhibit

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Product Name:
AHN 1-055 hydrochloride
Cat. No.:
HY-101315
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