1. Neuronal Signaling
  2. Dopamine Transporter
  3. Vanoxerine

Vanoxerine (Synonyms: GBR 12909; I893)

Cat. No.: HY-13217A
Handling Instructions

Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT).

For research use only. We do not sell to patients.

Vanoxerine Chemical Structure

Vanoxerine Chemical Structure

CAS No. : 67469-69-6

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Top Publications Citing Use of Products

    Vanoxerine purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.
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    Description

    Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT)[1].

    IC50 & Target

    Ki: 1 nM (dopamine reuptake)[1]

    In Vitro

    Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2].
    Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male mice(ddY strain at 6 weeks of age)[3]
    Dosage: 2.5, 5, 10, 20 mg/kg
    Administration: Intraperitoneal injection
    Result: The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
    Clinical Trial
    Molecular Weight

    450.56

    Formula

    C₂₈H₃₂F₂N₂O

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Product Name:
    Vanoxerine
    Cat. No.:
    HY-13217A
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