1. Neuronal Signaling
  2. Dopamine Transporter
  3. Vanoxerine

Vanoxerine (Synonyms: GBR 12909; I893)

Cat. No.: HY-13217A
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Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).

For research use only. We do not sell to patients.

Vanoxerine Chemical Structure

Vanoxerine Chemical Structure

CAS No. : 67469-69-6

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Top Publications Citing Use of Products

Publications Citing Use of MCE Vanoxerine

    Vanoxerine purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.
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    Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor). IC50 value: Target: Dopamine reuptake inhibitor At a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.

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