1. Neuronal Signaling
  2. Dopamine Transporter
  3. Vanoxerine

Vanoxerine (Synonyms: GBR 12909; I893)

Cat. No.: HY-13217A
Handling Instructions

Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).

For research use only. We do not sell to patients.

Vanoxerine Chemical Structure

Vanoxerine Chemical Structure

CAS No. : 67469-69-6

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10 mg USD 60 Get quote
50 mg USD 224 Get quote

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Top Publications Citing Use of Products

    Vanoxerine purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.
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    Description

    Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor). IC50 value: Target: Dopamine reuptake inhibitor At a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.

    Clinical Trial
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    Molecular Weight

    450.56

    Formula

    C₂₈H₃₂F₂N₂O

    CAS No.

    67469-69-6

    SMILES

    FC1=CC=C(C(C2=CC=C(F)C=C2)OCCN3CCN(CCCC4=CC=CC=C4)CC3)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Vanoxerine
    Cat. No.:
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    Vanoxerine

    Cat. No.: HY-13217A