1. Neuronal Signaling
  2. Serotonin Transporter
    Dopamine Transporter
  3. DOV-216,303 Free Base

DOV-216,303 Free Base 

Cat. No.: HY-18332C Purity: 98.47%
Handling Instructions

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats.

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DOV-216,303 Free Base Chemical Structure

DOV-216,303 Free Base Chemical Structure

CAS No. : 66504-40-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].

IC50 & Target

IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine)[1].

In Vivo

Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals[2].
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations[2].

Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2].
Dosage: 20 mg/kg.
Administration: I.P. daily for 17days.
Result: Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.
Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2].
Dosage: 20 mg/kg.
Administration: I.P. once.
Result: Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.
Molecular Weight

228.12

Formula

C₁₁H₁₁Cl₂N

CAS No.

66504-40-3

SMILES

ClC1=C(Cl)C=C(C=C1)C12CC1CNC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (547.96 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3837 mL 21.9183 mL 43.8366 mL
5 mM 0.8767 mL 4.3837 mL 8.7673 mL
10 mM 0.4384 mL 2.1918 mL 4.3837 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DOV-216,303Serotonin TransporterDopamine Transporter5-HTTSERTSLC6A4DATSLC6A3Inhibitorinhibitorinhibit

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Product name:
DOV-216,303 Free Base
Cat. No.:
HY-18332C
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