Amitifadine (Synonyms: DOV-21947; EB-1010)

Cat. No.: HY-18332: Data Sheet Handling Instructions
FAQs
Technical Support

Amitifadine (DOV-21947; EB-1010) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

For research use only. We do not sell to patients.

Amitifadine Chemical Structure

CAS No. : 410074-73-6

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Amitifadine:

Amitifadine hydrochloride

Other Forms of Amitifadine:

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms

Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	10 μM Compound: 4, DOV-21947	Inhibition of human ERG expressed in CHO cells Inhibition of human ERG expressed in CHO cells	[PMID: 18954985]
CHO	IC₅₀	93.8 nM Compound: 5, DOV-216303	Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells	[PMID: 20724153]
CHO-K1	IC₅₀	78 nM Compound: DOV-216, 303	Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation counting Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation counting	[PMID: 21093273]
CHO-K1	IC₅₀	96 nM Compound: DOV-21, 947	Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation counting Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation counting	[PMID: 21093273]
HEK293	IC₅₀	12 nM Compound: DOV-21, 947	Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting	[PMID: 21093273]
HEK293	IC₅₀	14 nM Compound: DOV-216, 303	Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting	[PMID: 21093273]
HEK293	IC₅₀	143 nM Compound: DOV216,303	Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	159.3 nM Compound: DOV21947	Inhibition of [3H]-DA uptake in human dopamine transporter expressed in HEK293 cells by scintillation counting Inhibition of [3H]-DA uptake in human dopamine transporter expressed in HEK293 cells by scintillation counting	[PMID: 25164761]
HEK293	IC₅₀	215 nM Compound: 5, DOV-216303	Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells	[PMID: 20724153]
HEK293	IC₅₀	394 nM Compound: DOV216,303	Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	411.5 nM Compound: DOV21947	Inhibition of [3H]-serotonin uptake in human SERT expressed in HEK293 cells by scintillation counting Inhibition of [3H]-serotonin uptake in human SERT expressed in HEK293 cells by scintillation counting	[PMID: 25164761]
HEK293	IC₅₀	71.4 nM Compound: DOV21947	Inhibition of [3H]-NE uptake in human norepinephrine transporter expressed in HEK293 cells by scintillation counting Inhibition of [3H]-NE uptake in human norepinephrine transporter expressed in HEK293 cells by scintillation counting	[PMID: 25164761]
HEK293	IC₅₀	723 nM Compound: DOV216,303	Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
MDCK	IC₅₀	20 nM Compound: DOV-216, 303	Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting	[PMID: 21093273]
MDCK	IC₅₀	23 nM Compound: DOV-21, 947	Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting	[PMID: 21093273]
MDCK	IC₅₀	72.4 nM Compound: 5, DOV-216303	Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells	[PMID: 20724153]

Molecular Weight

228.12

Formula

C₁₁H₁₁Cl₂N

CAS No.

410074-73-6

SMILES

ClC1=C(Cl)C=CC([C@]23[C@](CNC3)([H])C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. [Content Brief]

[2]. Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37. [Content Brief]

Amitifadine Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Amitifadine (Synonyms: DOV-21947; EB-1010)

Other Forms of Amitifadine:

Amitifadine Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Amitifadine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report