66504-40-3
66504-40-3
Chemical Structure
DOV-216,303 Free Base
- CAS No.: 66504-40-3
- Formula:C11H11Cl2N
- Molecular Weight:228.12
IUPAC Name: 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
InChIKey: BSMNRYCSBFHEMQ-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C=C(C=C1)C12CC1CNC2
Biological Activity: DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2].
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DOV-216,303 Free Base | 98.17% | DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats. | ||||||||||||||||||||
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References
Keywords
