1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Transporter
  3. Desipramine hydrochloride

Desipramine hydrochloride 

Cat. No.: HY-B1272 Purity: 99.68%
Handling Instructions

Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.

For research use only. We do not sell to patients.

Desipramine hydrochloride Chemical Structure

Desipramine hydrochloride Chemical Structure

CAS No. : 58-28-6

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10 mM * 1 mL in DMSO USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

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Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.

IC50 & Target

Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)[1]

In Vivo

Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay)[2].

Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.3 mg/mL (275.06 mM; Need ultrasonic and warming)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3021 mL 16.5104 mL 33.0207 mL
5 mM 0.6604 mL 3.3021 mL 6.6041 mL
10 mM 0.3302 mL 1.6510 mL 3.3021 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Rats are anesthetized with ketamine (100 mg/kg) and xylazine (10 mg/kg) and implanted subcutaneously with osmotic minipumps preloaded with either vehicle (50% saline, 40% DMSO, and 10% ethanol) or Desipramine hydrochloride at a concentration that delivered 5, 10, or 15 mg/kg per day of the free base. Minipumps are removed, under anesthesia, 14 days later. Rats are tested for antidepressant-like behavior in the forced-swim test 2 to 8 days after pump removal and discontinuation of Desipramine hydrochloride treatment. Following the completion of the behavioral tests, rats are killed by decapitation, their brains are removed, and cerebral cortex and hippocampus are dissected for neurochemical analyses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.68%

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