2. Others Neuronal Signaling GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt NF-κB Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease
  3. Reference Standards Adrenergic Receptor ERK JNK p38 MAPK NF-κB AP-1 Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism TNF Receptor
  4. Desipramine hydrochloride (Standard)

Desipramine hydrochloride (Standard) 

Cat. No.: HY-B1272R Purity: 99.03%
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Desipramine hydrochloride (Standard) is the analytical standard of Desipramine hydrochloride (HY-B1272). This product is intended for research and analytical applications. Desipramine hydrochloride is a first-generation tricyclic antidepressant. Desipramine hydrochloride selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine hydrochloride activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine hydrochloride also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine hydrochloride can be used for the research of hepatocellular cancer, inflammation, and neurological diseases.

For research use only. We do not sell to patients.

Desipramine hydrochloride (Standard)

Desipramine hydrochloride (Standard) Chemical Structure

CAS No. : 58-28-6

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Information

Desipramine hydrochloride (Standard) is the analytical standard of Desipramine hydrochloride (HY-B1272). This product is intended for research and analytical applications. Desipramine hydrochloride is a first-generation tricyclic antidepressant. Desipramine hydrochloride selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine hydrochloride activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine hydrochloride also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine hydrochloride can be used for the research of hepatocellular cancer, inflammation, and neurological diseases.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

302.84

Formula

C18H23ClN2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Desipramine hydrochloride (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desipramine hydrochloride (Standard)58-28-6Reference StandardsAdrenergic ReceptorERKJNKp38 MAPKNF-κBAP-1ApoptosisReactive Oxygen Species (ROS)Mitochondrial MetabolismTNF ReceptorBeta ReceptorExtracellular signal regulated kinasesc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBActivator Protein 1Tumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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