L-Allylglycine hydrochloride
Based on 1 publication(s) in Google Scholar
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 195316-72-4
- Formula: C5H10ClNO2
- Molecular Weight:151.59
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Allylglycine hydrochloride
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Customer Validation & Images
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats models[1].
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Dosage:150 mg/kg or 200 μg
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Administration:ip or intranigral injection, single dose
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Result:Reduced the GABA content in the hippocampus, cortex and cerebellum.
Induced running fits, partial rigidity, and convulsions in rats.
Chemical Information
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CAS No. 195316-72-4
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Appearance Solid
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Molecular Weight 151.59
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Formula C5H10ClNO2
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Color White to off-white
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Synonyms
L-2-Allylglycine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. [Abstract]2022 Dec;298(12):102603. PMID: 36265585
L-Allylglycine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2022 Dec;298(12):102603. [Abstract]
The effect of ACE2-mediated up-regulation of AKT phosphorylation is almost blocked by (S)-2-Allylglycine (Ally) (5 mM; 24 h) in HepG2 cells.
Solvent & Solubility
DMSO : 100 mg/mL (659.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. [Content Brief]
[2]. Beart PM, et al., Allylglycine: intranigral effects and reappraisal of actions on the GABA system. Biochem Pharmacol. 1979;28(4):449-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5967 mL | 32.9837 mL | 65.9674 mL | 164.9185 mL |
| 5 mM | 1.3193 mL | 6.5967 mL | 13.1935 mL | 32.9837 mL | |
| 10 mM | 0.6597 mL | 3.2984 mL | 6.5967 mL | 16.4919 mL | |
| 15 mM | 0.4398 mL | 2.1989 mL | 4.3978 mL | 10.9946 mL | |
| 20 mM | 0.3298 mL | 1.6492 mL | 3.2984 mL | 8.2459 mL | |
| 25 mM | 0.2639 mL | 1.3193 mL | 2.6387 mL | 6.5967 mL | |
| 30 mM | 0.2199 mL | 1.0995 mL | 2.1989 mL | 5.4973 mL | |
| 40 mM | 0.1649 mL | 0.8246 mL | 1.6492 mL | 4.1230 mL | |
| 50 mM | 0.1319 mL | 0.6597 mL | 1.3193 mL | 3.2984 mL | |
| 60 mM | 0.1099 mL | 0.5497 mL | 1.0995 mL | 2.7486 mL | |
| 80 mM | 0.0825 mL | 0.4123 mL | 0.8246 mL | 2.0615 mL | |
| 100 mM | 0.0660 mL | 0.3298 mL | 0.6597 mL | 1.6492 mL |
L-Allylglycine hydrochloride Related Classifications
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