1. Anti-infection
  2. Bacterial
  3. Gut restricted-7

Gut restricted-7 (Synonyms: GR-7)

Cat. No.: HY-135747
Handling Instructions

Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice.

For research use only. We do not sell to patients.

Gut restricted-7 Chemical Structure

Gut restricted-7 Chemical Structure

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Description

Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1].

IC50 & Target

Bile salt hydrolase (BSH)[1]

In Vitro

BSH Inhibitor Gut restricted-7 (GR-7) (60 μM) does not affect epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass[1].

In Vivo

The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (GR-7) (w/w) for 1 d day or powdered chow alone. Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitortreated mice 8 h postdiet change. 20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected[1].

Molecular Weight

510.63

Formula

C₂₅H₄₀FNaO₆S

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Gut restricted-7GR-7Gut restricted7Gut restricted 7GR7GR 7BacterialNontoxicBSHgutbileacidorallygut-restrictedbacterialInhibitorinhibitorinhibit

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Gut restricted-7
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HY-135747
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