1. Anti-infection
  2. Bacterial
  3. BSH-IN-1

BSH-IN-1 

Cat. No.: HY-135659
Handling Instructions

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.

For research use only. We do not sell to patients.

BSH-IN-1 Chemical Structure

BSH-IN-1 Chemical Structure

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Description

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively[1].

In Vitro

BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative (B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive (Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2–32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC50s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively[1].

In Vivo

BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage)inhibits BSH activity in C57BL/6 mice and can be gut-restricted[1].

Animal Model: C57BL/6 mice[1]
Dosage: 10 mg/kg
Administration: Single gavage
Result: Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.
Molecular Weight

408.59

Formula

C₂₅H₄₁FO₃

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BSH-IN-1BacterialgutbacterialbilesalthydrolasesBSHGrampositivenegativeInhibitorinhibitorinhibit

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BSH-IN-1
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HY-135659
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