1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Proteasome inhibitor IX

Proteasome inhibitor IX (Synonyms: PS-IX; AM114)

Cat. No.: HY-107412
Handling Instructions

Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity.

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Proteasome inhibitor IX Chemical Structure

Proteasome inhibitor IX Chemical Structure

CAS No. : 856849-35-9

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Description

Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity[1][2].

IC50 & Target

IC50: 1 μM (20S proteasome)[1]

In Vitro

Proteasome inhibitor IX (AM114; 0.1-10 µM; 14 days; HCT116 p53+/+ cells) treatment causes a loss of cell survival in the p53+/+ and p53-/- cells by approximately 70 and 20%, respectively at a concentration of 1 µM[1].
Proteasome inhibitor IX (AM114) exhibits potent activity against p53+/+ cells in colony formation assay, with an IC50 value of 0.6 µM[1].
Incubation of HCT116 p53+/+ cells with 1 µM Proteasome inhibitor IX (AM114) causes 28% of the cells to exhibit positive Annexin V staining at 48 h, and this fraction of dead cells increased to 76% at 72 h[1].
Proteasome inhibitor IX (AM114) treatment inhibits the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells[1].

Molecular Weight

377.01

Formula

C₂₀H₂₁B₂NO₅

CAS No.

856849-35-9

SMILES

O=C(/C(CN(C)C/1)=C\C2=CC=C(B(O)O)C=C2)C1=C/C3=CC=C(B(O)O)C=C3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Proteasome inhibitor IXPS-IXAM114AM 114AM-114ProteasomeAnticancerboronicacidEGCGcytotoxicChalconep53chymotrypsin-like20SubiquitinatedInhibitorinhibitorinhibit

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Proteasome inhibitor IX
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HY-107412
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