856849-35-9
Chemical Structure
Proteasome inhibitor IX
Synonym(s): PS-IX; AM114
- CAS No.: 856849-35-9
- Formula:C20H21B2NO5
- Molecular Weight:377.01
IUPAC Name: (((1Z,1'Z)-(1-methyl-4-oxopiperidine-3,5-diylidene)bis(methanylylidene))bis(4,1-phenylene))diboronic acid
InChIKey: SRPIKXGUPAKTIZ-APGQMXJTSA-N
SMILES: O=C(/C(CN(C)C/1)=C\C2=CC=C(B(O)O)C=C2)C1=C/C3=CC=C(B(O)O)C=C3
Biological Activity: Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Proteasome inhibitor IX | 98.01% | Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity. | ||||||||||||||||||||
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Proteasome inhibitor IX (Standard) | ≥98% | Proteasome inhibitor IX (Standard) is the analytical standard of Proteasome inhibitor IX (HY-107412). This product is intended for research and analytical applications. Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity. | ||||||||||||||||||||
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References
- [1]. Geetha Achanta , et al. A Boronic-Chalcone Derivative Exhibits Potent Anticancer Activity Through Inhibition of the Proteasome. Mol Pharmacol. 2006 Jul;70(1):426-33. [Content Brief]
- [2]. Encouse B Golden, et al. Green Tea Polyphenols Block the Anticancer Effects of Bortezomib and Other Boronic Acid-Based Proteasome Inhibitors. Blood. 2009 Jun 4;113(23):5927-37. [Content Brief]
