1. GPCR/G Protein
    Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. P2Y Receptor
    DNA/RNA Synthesis
    Endogenous Metabolite
  3. Uridine 5'-diphosphate sodium salt

Uridine 5'-diphosphate sodium salt 

Cat. No.: HY-W010820
Handling Instructions

Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

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Uridine 5'-diphosphate sodium salt Chemical Structure

Uridine 5'-diphosphate sodium salt Chemical Structure

CAS No. : 21931-53-3

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Description

Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].

RT-PCR[2]

Cell Line: Primary microglia
Concentration: 100 μM
Incubation Time: For 15 min
Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.
Formula

C₉H₁₄N₂O₁₂P₂.xNa

CAS No.

21931-53-3

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C(NC(C=C1)=O)=O)O2)O)[[email protected]]2COP(O)(OP(O)(O)=O)=O.[Na+].[x]

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Keywords:

Uridine 5'-diphosphateP2Y ReceptorDNA/RNA SynthesisEndogenous MetaboliteP2Y6P2Y14glucuronidationsubstratesnucleicacidInhibitorinhibitorinhibit

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Uridine 5'-diphosphate sodium salt
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HY-W010820
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