Uridine 5'-diphosphate sodium salt 

Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis^[1][2].

Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression^[2].
Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia^[2].
Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h^[2].
UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level^[2].
Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₉H₁₄N₂O₁₂P₂.xNa

21931-53-3

O[C@@H]([C@H]([C@H](N1C(NC(C=C1)=O)=O)O2)O)[C@H]2COP(O)(OP(O)(O)=O)=O.[Na+].[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89.  [Content Brief]

  [2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.  [Content Brief]