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Cat. No.: HY-113359

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Uridine 5'-diphosphate

(Synonyms: UDP)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Uridine 5'-diphosphate (UDP) is a P2Y₆ receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

For research use only. We do not sell to patients.

CAS No.: 58-98-0
Formula: C₉H₁₄N₂O₁₂P₂
Molecular Weight:404.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Uridine 5'-diphosphate Chemical Structure

CAS No.: 58-98-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Uridine 5'-diphosphate (UDP) is a P2Y₆ receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor^[1]^[2].

IC₅₀ & Target^[1]

P2Y6 Receptor

0.013 μM (EC₅₀)

Human Endogenous Metabolite

All P2Y Receptor Isoforms :

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	EC₅₀	160 μM Compound: 2, UDP	Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta	[PMID: 25868749]
HEK293	EC₅₀	0.16 μM Compound: 1, UDP	Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay	[PMID: 20446735]
HEK293	EC₅₀	160 nM Compound: 3	Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production	[PMID: 19902968]

In Vitro

Uridine 5'-diphosphate stimulates phospholipase C (PLC) in 1321N1 astrocytoma cells (EC₅₀ = 86 nM)^[1].
Uridine 5'-diphosphate act as a carrier of activated sugars, such as glucose^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 58-98-0
Molecular Weight 404.16
Formula C₉H₁₄N₂O₁₂P₂
SMILES

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)NC1=O
Synonyms

UDP
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Free Radic Biol Med

P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy. [Abstract]

2025 Oct 17:242:203-219. PMID: 41110517

Uridine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

UDP (Uridine-5'-diphosphate disodium salt) agonism elicited distinct signaling responses, enhancing CaMKII, p-PKC, and SOD2, while suppressing Nrf2 and HO-1, without altering p62, VPS34, LC3B, AMPKα, or mTOR. In contrast, MRS treatment selectively increased HO-1 phosphorylation, while leaving other pathways unaffected.

Uridine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

Schematic representing the relationship between MRS2578, P2Y6, UDP (Uridine-5'-diphosphate disodium salt), and MRS2693.
Int Immunopharmacol

Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice. [Abstract]

2022 Aug:109:108909. PMID: 35700583

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Besada P, et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43. [Content Brief]

[2]. Pâris A, et al. Simultaneous one-pot multienzymatic synthesis and purification of Uridine-5'-Diphosphate-α-D-glucuronide and Uridine-5'-Diphosphate-α-d-xylose. Carbohydr Res. 2025 Aug;554:109516. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Uridine 5'-diphosphate

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References

1/16
1/16

Uridine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

Customer Validation
UDP (Uridine-5'-diphosphate disodium salt) agonism elicited distinct signaling responses, enhancing CaMKII, p-PKC, and SOD2, while suppressing Nrf2 and HO-1, without altering p62, VPS34, LC3B, AMPKα, or mTOR. In contrast, MRS treatment selectively increased HO-1 phosphorylation, while leaving other pathways unaffected.
1/16

Uridine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

Customer Validation
Schematic representing the relationship between MRS2578, P2Y6, UDP (Uridine-5'-diphosphate disodium salt), and MRS2693.

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Uridine 5'-diphosphate

Publications Citing Use of MedChemExpress (MCE) Uridine 5'-diphosphate

All P2Y Receptor Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Uridine 5'-diphosphate Related Classifications

HY-113359 Related Classifications