58-98-0
Chemical Structure
Uridine 5'-diphosphate
Synonym(s): UDP
- CAS No.: 58-98-0
- Formula:C9H14N2O12P2
- Molecular Weight:404.16
IUPAC Name: ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
InChIKey: XCCTYIAWTASOJW-XVFCMESISA-N
SMILES: O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)NC1=O
Biological Activity: Uridine-5'-diphosphate (UDP) is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
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Uridine 5'-diphosphate | Uridine-5'-diphosphate (UDP) is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | |||||||||||||||||||||
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Uridine 5'-diphosphate-d12 dilithium | Uridine 5'-diphosphate-d12 (UDP-d12) dilithium is the d12-labeled Uridine 5'-diphosphate (HY-113359). Uridine-5'-diphosphate is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | |||||||||||||||||||||
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Uridine 5'-diphosphate-13C9 dilithium | Uridine 5'-diphosphate-13C9 (UDP-13C9 ) dilithium is 13C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor. | |||||||||||||||||||||
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Uridine 5'-diphosphate-13C9,15N2 dilithium | 99.5% | Uridine 5'-diphosphate-13C9,15N2 (UDP-13C9,15N2) dilithium is the 13C9,15N2-labeled Uridine 5'-diphosphate (HY-113359). Uridine-5'-diphosphate is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | ||||||||||||||||||||
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Uridine 5'-diphosphate-15N2 dilithium | Uridine 5'-diphosphate-15N2 (UDP-15N2) dilithium is the 15N2-labeled Uridine 5'-diphosphate (HY-113359). Uridine-5'-diphosphate is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | |||||||||||||||||||||
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References
- [1]. Besada P, et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43. [Content Brief]
- [2]. Pâris A, et al. Simultaneous one-pot multienzymatic synthesis and purification of Uridine-5'-Diphosphate-α-D-glucuronide and Uridine-5'-Diphosphate-α-d-xylose. Carbohydr Res. 2025 Aug;554:109516. [Content Brief]
