Uridine 5'-diphosphate sodium
Uridine-5'-diphosphate (UDP) sodium is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate sodium is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate sodium, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
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- CAS No.: 19817-91-5
- Formula: C9H11N2Na3O12P2
- Molecular Weight:470.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All P2Y Receptor Isoforms
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
EC50: 300 nM (P2Y6)[1]
pEC50: 6.52 (P2Y6)[1]
Uridine-5'-diphosphate (100 μM; 15 min) sodium significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine-5'-diphosphate (100 μM; 3 h) sodium induces chemokine expression in microglia[2].
Uridine-5'-diphosphate (100 μM; 0.5-12 h) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
Uridine-5'-diphosphate (10-1000 μM; 3 h) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine-5'-diphosphate (10-1000 μM; 3 h) induces activation of NFATc1 and NFATc2 in microglia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary microglia
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Concentration:100 μM
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Incubation Time:For 15 min
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Result:Significantly induced microglial CCL2 and CCL3 mRNA expression.
Chemical Information
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CAS No. 19817-91-5
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Molecular Weight 470.11
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Formula C9H11N2Na3O12P2
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[Na])(O[Na])=O)(O[Na])=O)O2)NC1=O
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Synonyms
UDP sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. [Content Brief]
[2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9. [Content Brief]
[3]. Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7(43):69358-69370. [Content Brief]
[4]. Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Uridine 5'-diphosphate sodium Related Classifications
HY-W1058220 Related Classifications
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