Uridine-5'-diphosphate disodium salt

Name: Uridine-5'-diphosphate disodium salt
Brand: MedChemExpress
SKU: HY-W010832
Rating: 4.5 (1 reviews)

Cat. No.: HY-W010832 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Uridine-5'-diphosphate disodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52 for human P2Y₆ receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

For research use only. We do not sell to patients.

Uridine-5'-diphosphate disodium salt Chemical Structure

CAS No. : 27821-45-0

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Uridine-5'-diphosphate disodium salt:

Uridine 5'-diphosphate sodium salt Get quote

1 Publications Citing Use of MCE Uridine-5'-diphosphate disodium salt

•Int Immunopharmacol. August 2022, 108909.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

P2Y6 Receptor

In Vitro

Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression^[2].
Uridine-5'-diphosphate disodium salt (100 μM; 3 hours) induces chemokine expression in microglia^[2].
Uridine-5'-diphosphate disodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h^[2].
Uridine-5'-diphosphate disodium salt (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level^[2].
Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia^[2].
Uridine-5'-diphosphate disodium salt is a competitive antagonist at the human P2Y₁₄ receptor (pEC₅₀=7.28) but not rat P2Y₁₄ receptor^[1].
UDP-glucose (UDPG; HY-N7032) is a potent P2Y₁₄ agonist^[3]^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:	Primary microglia
Concentration:	100 μM
Incubation Time:	For 15 min
Result:	Significantly induced microglial CCL2 and CCL3 mRNA expression.

Molecular Weight

448.12

Formula

C₉H₁₂N₂Na₂O₁₂P₂

CAS No.

27821-45-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](N(C=CC2=O)C(N2)=O)O[C@H](COP(OP(O)(O[Na])=O)(O[Na])=O)[C@H]1O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (223.15 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2315 mL	11.1577 mL	22.3155 mL
5 mM	0.4463 mL	2.2315 mL	4.4631 mL
10 mM	0.2232 mL	1.1158 mL	2.2315 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (223.15 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (253 KB) HNMR (230 KB)

Handling Instructions (2659 KB)

References

[1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. [Content Brief]

[2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9. [Content Brief]

[3]. Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7(43):69358-69370. [Content Brief]

[4]. Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2315 mL	11.1577 mL	22.3155 mL	55.7886 mL
	5 mM	0.4463 mL	2.2315 mL	4.4631 mL	11.1577 mL
	10 mM	0.2232 mL	1.1158 mL	2.2315 mL	5.5789 mL
	15 mM	0.1488 mL	0.7438 mL	1.4877 mL	3.7192 mL
	20 mM	0.1116 mL	0.5579 mL	1.1158 mL	2.7894 mL
	25 mM	0.0893 mL	0.4463 mL	0.8926 mL	2.2315 mL
	30 mM	0.0744 mL	0.3719 mL	0.7438 mL	1.8596 mL
	40 mM	0.0558 mL	0.2789 mL	0.5579 mL	1.3947 mL
	50 mM	0.0446 mL	0.2232 mL	0.4463 mL	1.1158 mL
	60 mM	0.0372 mL	0.1860 mL	0.3719 mL	0.9298 mL
	80 mM	0.0279 mL	0.1395 mL	0.2789 mL	0.6974 mL
	100 mM	0.0223 mL	0.1116 mL	0.2232 mL	0.5579 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.