Uridine-5'-diphosphate disodium salt
Based on 2 publication(s) in Google Scholar
Uridine-5'-diphosphate (UDP) disodium salt is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate disodium salt is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 27821-45-0
- Formula: C9H12N2Na2O12P2
- Molecular Weight:448.12
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-W010918
Adenosine 5'-diphosphate
-
HY-W013093
Uridine triphosphate trisodium salt
-
HY-13104
MRS 2578
-
HY-101981
Uridine 5'-monophosphate
-
HY-N7032
Uridine 5′-diphosphoglucose disodium
-
HY-W009162
Cytidine 5'-monophosphate
-
HY-114364
UDP-Galactose disodium
-
HY-W008915
Cytidine 5'-diphosphate trisodium salt
-
HY-113066A
Guanosine 5'-diphosphate disodium salt
-
HY-B2176
ATP
-
HY-A0181
Adenosine monophosphate
-
HY-N0230
β-Alanine
Publications Citing Use of MedChemExpress (MCE) Uridine-5'-diphosphate disodium salt
More
Customer Validation & Images
-
WB
-
Others
All P2Y Receptor Isoforms
MoreAll DNA/RNA Synthesis Isoforms
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
|
P2Y6 Receptor |
Uridine-5'-diphosphate (100 μM; 15 min) disodium salt significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine-5'-diphosphate (100 μM; 3 h) disodium salt induces chemokine expression in microglia[2].
Uridine-5'-diphosphate (100 μM; 0.5-12 h) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
Uridine-5'-diphosphate (10-1000 μM; 3 h) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine-5'-diphosphate (10-1000 μM; 3 h) induces activation of NFATc1 and NFATc2 in microglia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Primary microglia
-
Concentration:100 μM
-
Incubation Time:For 15 min
-
Result:Significantly induced microglial CCL2 and CCL3 mRNA expression.
Chemical Information
-
CAS No. 27821-45-0
-
Appearance Solid
-
Molecular Weight 448.12
-
Formula C9H12N2Na2O12P2
-
Color White to off-white
-
SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O2)NC1=O
-
Synonyms
UDP disodium salt
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Free Radic Biol Med
P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy. [Abstract]2025 Oct 17:242:203-219. PMID: 41110517
Uridine-5'-diphosphate disodium salt purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
UDP (Uridine-5'-diphosphate disodium salt) agonism elicited distinct signaling responses, enhancing CaMKII, p-PKC, and SOD2, while suppressing Nrf2 and HO-1, without altering p62, VPS34, LC3B, AMPKα, or mTOR. In contrast, MRS treatment selectively increased HO-1 phosphorylation, while leaving other pathways unaffected.
Uridine-5'-diphosphate disodium salt purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
Schematic representing the relationship between MRS2578, P2Y6, UDP (Uridine-5'-diphosphate disodium salt), and MRS2693.
-
Int Immunopharmacol
Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice. [Abstract]2022 Aug:109:108909. PMID: 35700583
Solvent & Solubility
H2O : 100 mg/mL (223.15 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (223.15 mM); Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. [Content Brief]
[2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9. [Content Brief]
[3]. Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7(43):69358-69370. [Content Brief]
[4]. Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2315 mL | 11.1577 mL | 22.3155 mL | 55.7886 mL |
| 5 mM | 0.4463 mL | 2.2315 mL | 4.4631 mL | 11.1577 mL | |
| 10 mM | 0.2232 mL | 1.1158 mL | 2.2315 mL | 5.5789 mL | |
| 15 mM | 0.1488 mL | 0.7438 mL | 1.4877 mL | 3.7192 mL | |
| 20 mM | 0.1116 mL | 0.5579 mL | 1.1158 mL | 2.7894 mL | |
| 25 mM | 0.0893 mL | 0.4463 mL | 0.8926 mL | 2.2315 mL | |
| 30 mM | 0.0744 mL | 0.3719 mL | 0.7438 mL | 1.8596 mL | |
| 40 mM | 0.0558 mL | 0.2789 mL | 0.5579 mL | 1.3947 mL | |
| 50 mM | 0.0446 mL | 0.2232 mL | 0.4463 mL | 1.1158 mL | |
| 60 mM | 0.0372 mL | 0.1860 mL | 0.3719 mL | 0.9298 mL | |
| 80 mM | 0.0279 mL | 0.1395 mL | 0.2789 mL | 0.6974 mL | |
| 100 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5579 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Uridine-5'-diphosphate disodium salt Related Classifications
HY-W010832 Related Classifications
Powered by Bioz