1. GPCR/G Protein
    Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. P2Y Receptor
    DNA/RNA Synthesis
    Endogenous Metabolite
  3. Uridine-5'-diphosphate disodium salt

Uridine-5'-diphosphate disodium salt 

Cat. No.: HY-W010832 Purity: >98.0%
Handling Instructions

Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

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Uridine-5'-diphosphate disodium salt Chemical Structure

Uridine-5'-diphosphate disodium salt Chemical Structure

CAS No. : 27821-45-0

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10 mM * 1  mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine-5'-diphosphate disodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine-5'-diphosphate disodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
Uridine-5'-diphosphate disodium salt (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].

RT-PCR[2]

Cell Line: Primary microglia
Concentration: 100 μM
Incubation Time: For 15 min
Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.
Molecular Weight

448.12

Formula

C₉H₁₂N₂Na₂O₁₂P₂

CAS No.

27821-45-0

SMILES

O[[email protected]]1[[email protected]](N(C=CC2=O)C(N2)=O)O[[email protected]](COP(OP([O-])(O)=O)([O-])=O)[[email protected]]1O.[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (223.15 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2315 mL 11.1577 mL 22.3155 mL
5 mM 0.4463 mL 2.2315 mL 4.4631 mL
10 mM 0.2232 mL 1.1158 mL 2.2315 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

Uridine-5'-diphosphate disodiumP2Y ReceptorDNA/RNA SynthesisEndogenous MetaboliteP2Y6P2Y14glucuronidationsubstratesnucleicacidInhibitorinhibitorinhibit

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Uridine-5'-diphosphate disodium salt
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