Uridine 5′-diphosphoglucose disodium salt (Synonyms: UDP-D-Glucose disodium salt)

Name: Uridine 5′-diphosphoglucose disodium salt
Brand: MedChemExpress
SKU: HY-N7032
Rating: 4.5 (3 reviews)

Cat. No.: HY-N7032 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

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Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y₁₄ receptor, a neuroimmune system GPCR.

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Uridine 5′-diphosphoglucose disodium salt Chemical Structure

CAS No. : 28053-08-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 35	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 35	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 3 publication(s) in Google Scholar

Other Forms of Uridine 5′-diphosphoglucose disodium salt:

Uridine 5′-diphosphoglucose-¹³C₆ disodium In-stock
Uridine diphosphate glucose Get quote
Uridine 5′-diphosphoglucose-¹³C disodium Get quote

3 Publications Citing Use of MCE Uridine 5′-diphosphoglucose disodium salt

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

P2Y14 Receptor

Microbial Metabolite

Molecular Weight

610.27

Formula

C₁₅H₂₂N₂Na₂O₁₇P₂

CAS No.

28053-08-9

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@](N2C(NC(C=C2)=O)=O)([H])O[C@@H]([C@H]1O)COP(OP(O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)(O[Na])=O)(O[Na])=O

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Solvent & Solubility

In Vitro:

H₂O : ≥ 250 mg/mL (409.65 mM)

DMSO : 115 mg/mL (188.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6386 mL	8.1931 mL	16.3862 mL
5 mM	0.3277 mL	1.6386 mL	3.2772 mL
10 mM	0.1639 mL	0.8193 mL	1.6386 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (8.19 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.55 mg/mL (0.90 mM); Clear solution

This protocol yields a clear solution of ≥ 0.55 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (163.86 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (274 KB) SDS (0 KB)

COA (250 KB) HNMR (345 KB) RP-HPLC (136 KB) LCMS (123 KB)

Handling Instructions (2659 KB)

References

[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.

[2]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.6386 mL	8.1931 mL	16.3862 mL	40.9655 mL
	5 mM	0.3277 mL	1.6386 mL	3.2772 mL	8.1931 mL
	10 mM	0.1639 mL	0.8193 mL	1.6386 mL	4.0965 mL
	15 mM	0.1092 mL	0.5462 mL	1.0924 mL	2.7310 mL
	20 mM	0.0819 mL	0.4097 mL	0.8193 mL	2.0483 mL
	25 mM	0.0655 mL	0.3277 mL	0.6554 mL	1.6386 mL
	30 mM	0.0546 mL	0.2731 mL	0.5462 mL	1.3655 mL
	40 mM	0.0410 mL	0.2048 mL	0.4097 mL	1.0241 mL
	50 mM	0.0328 mL	0.1639 mL	0.3277 mL	0.8193 mL
	60 mM	0.0273 mL	0.1366 mL	0.2731 mL	0.6828 mL
	80 mM	0.0205 mL	0.1024 mL	0.2048 mL	0.5121 mL
	100 mM	0.0164 mL	0.0819 mL	0.1639 mL	0.4097 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Uridine 5′-diphosphoglucose disodium salt Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5′-diphosphoglucose disodium28053-08-9UDP-D-Glucose disodiumEndogenous MetaboliteP2Y ReceptorInhibitorinhibitorinhibit

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Uridine 5′-diphosphoglucose disodium salt (Synonyms: UDP-D-Glucose disodium salt)

Customer Review

Other Forms of Uridine 5′-diphosphoglucose disodium salt:

Uridine 5′-diphosphoglucose disodium salt Related Antibodies

3 Publications Citing Use of MCE Uridine 5′-diphosphoglucose disodium salt

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•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

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Complete Stock Solution Preparation Table

Uridine 5′-diphosphoglucose disodium salt Related Classifications

Keywords:

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