Cat. No.: HY-113044

Uridine 5′-diphosphoglucose

(Synonyms: UDP-D-Glucose)

8 Cited Publications

고객리뷰

Based on 8 publication(s) in Google Scholar

Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

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CAS No.: 133-89-1
화학식: C₁₅H₂₄N₂O₁₇P₂
분자량:566.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Uridine 5′-diphosphoglucose Chemical Structure

CAS No.: 133-89-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (8)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Human Endogenous Metabolite

P2Y14 Receptor

Microbial Metabolite

All Endogenous Metabolite Isoforms :

All P2Y Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	EC₅₀	0.261 μM Compound: 1	Agonist activity at human P2Y14 receptor expressed in human COS7 cells Agonist activity at human P2Y14 receptor expressed in human COS7 cells	[PMID: 19502066]
COS-7	EC₅₀	0.35 μM Compound: 1	Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis	[PMID: 17407275]
COS-7	EC₅₀	354 nM Compound: 1, UDP-glucose	Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC	[PMID: 17088057]
COS-7	EC₅₀	400 μM Compound: 1, UDPG	Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta	[PMID: 25868749]
HEK293	EC₅₀	400 nM Compound: 1	Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production	[PMID: 19902968]

In Vitro

Uridine 5’-diphosphoglucose (0-100 μM, 24 h) upregulates the expression of P2Y14 receptor, which induces neutrophil apoptos^[2].
Uridine 5’-diphosphoglucose (1 μM, 24 h) and PPTN (HY-110322A) result in suppressed mRNA level of inflammatory factors including CCL3, IL1β,IL12a, TNF-α in neutrophils compared to cells treated with Uridine 5’-diphosphoglucose disodium salt alone, on the contrary, anti-inflammatory factors including IL10, TGF-β1, YM1 are upregulated upon Uridine 5’-diphosphoglucose disodium salt and PPTN (HY-110322A) in neutrophils^[2].
Depletion of the pools of uridine 5’-diphosphoglucose (5 or 20 mM, incubation for 3 h) in the liver of the rat was associated with decreased glycosylation of secreted and tissue glycoproteins, influencing the rate of glomerular basement membrane (GBM) synthesis in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Neutrophils
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Decreased cell viability and elevated apoptosis of neutrophils, which was blunted by PPTN (HY-110322A).

Cell Migration Assay ^[2]

Cell Line:

Neutrophils
Concentration:

1 μM
Incubation Time:

24 h
Result:

Resulted in impaired neutrophil migration, which was inverted by PPTN (HY-110322A).

Chemical Information

CAS No. 133-89-1
분자량 566.30
화학식 C₁₅H₂₄N₂O₁₇P₂
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(O)(OP(O)(O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)=O)=O)O[C@H]1N3C=CC(NC3=O)=O
Synonyms

UDP-D-Glucose
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (8)

All RT-PCRWB

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Journal Impact Factor

Mol Plant

Metabolomic remodeling and genetic regulation in potato tubers during domestication. [Abstract]

2025 Dec 13:S1674-2052(25)00435-6. PMID: 41392480
J Am Chem Soc

Next-Generation Total Synthesis of Vancomycin. [Abstract]

2020 Sep 16;142(37):16039-16050. PMID: 32885969
Cell Rep

Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG. [Abstract]

2025 Nov 18;44(12):116577. PMID: 41259203
BMC Cancer

Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy. [Abstract]

2025 Jun 1;25(1):982. PMID: 40452021

Uridine 5′-diphosphoglucose purchased from MedChemExpress. Usage Cited in: BMC Cancer. 2025 Jun 1;25(1):982. [Abstract]

Cellular Thermal Shift Assay was performed to detect the interactions between molecules and INF2 protein.The results demonstrated that the thermal stability of INF2 proteins was no significantly changed after treatment with Uridine 5′-diphosphoglucose disodium (10 μM; 24 h) and Alginic acid.
Clin Immunol

Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus. [Abstract]

2024 Aug:265:110300. PMID: 38950722

Uridine 5′-diphosphoglucose purchased from MedChemExpress. Usage Cited in: Clin Immunol. 2024 Aug:265:110300. [Abstract]

RNA levels of inflammatory genes in Uridine 5′-diphosphoglucose disodium (UDP-G, 25–100 μM; 24) treated DC2.4 (murine DC cell line) cells. The results showed that UDP-G (25-100 μM) significantly upregulated the expression levels of Cxcl9, Cxcl10, and Il23 in treated mouse DC cells (DC2.4 cell line).
SSRN

2024 Jul 16.
Evid Based Complement Alternat Med

Isoschaftoside Inhibits Lipopolysaccharide-Induced Inflammation in Microglia through Regulation of HIF-1 α-Mediated Metabolic Reprogramming. [Abstract]

2022 Nov 23:2022:5227335. PMID: 36467557
Research Square Preprint

2021 Nov.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.

[2]. Li K, et al. Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury[J]. Life Sci. 2023 Aug 1;326:121805. [Content Brief]

[3]. Cortes P, Dumler F, Levin NW. De novo pyrimidine nucleotide biosynthesis in isolated rat glomerul[J]i. Kidney Int. 1986 Jul;30(1):27-34. [Content Brief]

[4]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Uridine 5′-diphosphoglucose

8 Cited Publications

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Uridine 5′-diphosphoglucose