Uridine 5′-diphosphoglucose (Synonyms: UDP-D-Glucose)

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Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Uridine 5′-diphosphoglucose disodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

CAS No. : 133-89-1

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Other Forms of Uridine 5′-diphosphoglucose:

Uridine 5′-diphosphoglucose-¹³C disodium In-stock
Uridine 5′-diphosphoglucose-¹³C₆ disodium In-stock
Uridine 5′-diphosphoglucose disodium In-stock
Uridine 5′-diphosphoglucose (Standard) In-stock

8 Publications Citing Use of MCE Uridine 5′-diphosphoglucose

RT-PCR

: Uridine 5′-diphosphoglucose purchased from MedChemExpress. Usage Cited in: BMC Cancer. 2025 Jun 1;25(1):982. [Abstract]; Cellular Thermal Shift Assay was performed to detect the interactions between molecules and INF2 protein.The results demonstrated that the thermal stability of INF2 proteins was no significantly changed after treatment with Uridine 5′-diphosphoglucose disodium (10 μM; 24 h) and Alginic acid.

: Uridine 5′-diphosphoglucose purchased from MedChemExpress. Usage Cited in: Clin Immunol. 2024 Jun 29:110300. [Abstract]; RNA levels of inflammatory genes in Uridine 5′-diphosphoglucose disodium (UDP-G, 25–100 μM; 24) treated DC2.4 (murine DC cell line) cells. The results showed that UDP-G (25-100 μM) significantly upregulated the expression levels of Cxcl9, Cxcl10, and Il23 in treated mouse DC cells (DC2.4 cell line).

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Purity & Documentation
References
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Description

IC₅₀ & Target

Human Endogenous Metabolite

P2Y14 Receptor

Microbial Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	EC₅₀	0.261 μM Compound: 1	Agonist activity at human P2Y14 receptor expressed in human COS7 cells Agonist activity at human P2Y14 receptor expressed in human COS7 cells	[PMID: 19502066]
COS-7	EC₅₀	0.35 μM Compound: 1	Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis	[PMID: 17407275]
COS-7	EC₅₀	354 nM Compound: 1, UDP-glucose	Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC	[PMID: 17088057]
COS-7	EC₅₀	400 μM Compound: 1, UDPG	Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta	[PMID: 25868749]
HEK293	EC₅₀	400 nM Compound: 1	Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production	[PMID: 19902968]

In Vitro

Uridine 5’-diphosphoglucose (0-100 μM, 24 h) upregulates the expression of P2Y14 receptor, which induces neutrophil apoptos^[2].
Uridine 5’-diphosphoglucose (1 μM, 24 h) and PPTN (HY-110322A) result in suppressed mRNA level of inflammatory factors including CCL3, IL1β,IL12a, TNF-α in neutrophils compared to cells treated with Uridine 5’-diphosphoglucose disodium salt alone, on the contrary, anti-inflammatory factors including IL10, TGF-β1, YM1 are upregulated upon Uridine 5’-diphosphoglucose disodium salt and PPTN (HY-110322A) in neutrophils^[2].
Depletion of the pools of uridine 5’-diphosphoglucose (5 or 20 mM, incubation for 3 h) in the liver of the rat was associated with decreased glycosylation of secreted and tissue glycoproteins, influencing the rate of glomerular basement membrane (GBM) synthesis in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Neutrophils
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Decreased cell viability and elevated apoptosis of neutrophils, which was blunted by PPTN (HY-110322A).

Cell Migration Assay ^[2]

Cell Line:	Neutrophils
Concentration:	1 μM
Incubation Time:	24 h
Result:	Resulted in impaired neutrophil migration, which was inverted by PPTN (HY-110322A).

Molecular Weight

566.30

Formula

C₁₅H₂₄N₂O₁₇P₂

CAS No.

133-89-1

SMILES

O[C@@H]1[C@H](O)[C@@H](COP(O)(OP(O)(O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)=O)=O)O[C@H]1N3C=CC(NC3=O)=O

Structure Classification

Others

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.

[2]. Li K, et al. Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury[J]. Life Sci. 2023 Aug 1;326:121805. [Content Brief]

[3]. Cortes P, Dumler F, Levin NW. De novo pyrimidine nucleotide biosynthesis in isolated rat glomerul[J]i. Kidney Int. 1986 Jul;30(1):27-34. [Content Brief]

[4]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. [Content Brief]

Uridine 5′-diphosphoglucose Related Classifications

Metabolic Disease Inflammation/Immunology Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5′-diphosphoglucose133-89-1UDP-D-GlucoseEndogenous MetaboliteP2Y ReceptorUridine5′-diphosphoglucosedisodiumendogenousmetaboliteP2YreceptorInhibitorinhibitorinhibit

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