Cat. No.: HY-N0230

β-Alanine

(Synonyms: 2-Carboxyethylamine; 3-Aminopropanoic acid)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 107-95-9
Formula: C₃H₇NO₂
Molecular Weight:89.09

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

β-Alanine Chemical Structure

CAS No.: 107-95-9

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>100 μM Compound: beta-alanine	Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 25147609]
CHO	IC₅₀	209 μM Compound: beta-alanine	Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 23886812]
CHO	IC₅₀	41.2 μM Compound: beta-alanine	Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 23886812]
CHO	IC₅₀	41.2 μM Compound: beta-alanine	Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 25147609]

In Vitro

Cells treated with β-alanine display significantly suppressed basal and peak ECAR (aerobic glycolysis), with simultaneous increase in glucose transporter 1 (GLUT1). Additionally, cells treated with β-alanine exhibit significantly reduced basal and peak OCR (oxidative metabolism), which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis. Suppression of glycolytic and oxidative metabolism by β-alanine results in the reduction of total metabolic rate, although cell viability is not affected.β-alanine is shown to reduce both cell migration and proliferation without acting in a cytotoxic fashion. Moreover, β-alanine significantly increases malignant cell sensitivity to doxorubicin, suggesting a potential role as a co-therapeutic agent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 107-95-9
Appearance Solid
Molecular Weight 89.09
Formula C₃H₇NO₂
Color White to off-white
SMILES

NCCC(O)=O
Synonyms

2-Carboxyethylamine; 3-Aminopropanoic acid
Structure Classification
- Amino acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

All WBRT-PCRIn Vivo Efficacy StudyIHC

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Death Differ

AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy. [Abstract]

2025 Sep 23. PMID: 40987895

β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23. [Abstract]

Western blotting assays revealed that compared with DN mice, DN+β-Alanine (836 mg/kg/day) mice presented decreased AARS1, H3K18la, STAT1, ELOVL5, and ACSL4 levels and increased GPX4 expression in kidney tissues.

β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23. [Abstract]

qPCR assays indicated that compared with DN mice, DN+β-Alanine (836 mg/kg/day) mice presented decreased AARS1, STAT1 and ELOVL5 mRNA expression in kidney tissues.

β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23. [Abstract]

Compared with those in DN model mice, the MDA levels were decreased in the kidneys of DN+β-Alanine (836 mg/kg/day) model mice.

β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23. [Abstract]

Compared with those in DN mice, LPO levels were decreased in the kidneys of DN+β-Alanine (836 mg/kg/day) model mice.

β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23. [Abstract]

Immunohistochemical staining and transmission electron microscopy (TEM) images of GPX4 in kidney biopsy samples from mice in the control group (Con), β-Alanine group (836 mg/kg/day), diabetic nephropathy (DN) group, and DN+β-alanine group.
Cell Rep

Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming. [Abstract]

2026 Mar 28;45(4):117208. PMID: 41904954
Cell Rep

High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy. [Abstract]

2025 Apr 9;44(4):115545. PMID: 40215164

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (1122.41 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

11.2241 mL

56.1205 mL

112.2410 mL

5 mM

2.2448 mL

11.2241 mL

22.4482 mL

10 mM

1.1224 mL

5.6121 mL

11.2241 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (561.21 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vaughan RA, et al. β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer. 2014 Jan 24;13:14. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	11.2241 mL	56.1205 mL	112.2410 mL	280.6025 mL
	5 mM	2.2448 mL	11.2241 mL	22.4482 mL	56.1205 mL
	10 mM	1.1224 mL	5.6121 mL	11.2241 mL	28.0603 mL
	15 mM	0.7483 mL	3.7414 mL	7.4827 mL	18.7068 mL
	20 mM	0.5612 mL	2.8060 mL	5.6121 mL	14.0301 mL
	25 mM	0.4490 mL	2.2448 mL	4.4896 mL	11.2241 mL
	30 mM	0.3741 mL	1.8707 mL	3.7414 mL	9.3534 mL
	40 mM	0.2806 mL	1.4030 mL	2.8060 mL	7.0151 mL
	50 mM	0.2245 mL	1.1224 mL	2.2448 mL	5.6121 mL
	60 mM	0.1871 mL	0.9353 mL	1.8707 mL	4.6767 mL
	80 mM	0.1403 mL	0.7015 mL	1.4030 mL	3.5075 mL
	100 mM	0.1122 mL	0.5612 mL	1.1224 mL	2.8060 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Alanine

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Publications Citing Use of MedChemExpress (MCE) β-Alanine

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

β-Alanine Related Classifications

HY-N0230 Related Classifications