2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. β-Alanine

β-Alanine  (Synonyms: 2-Carboxyethylamine; 3-Aminopropanoic acid)

Cat. No.: HY-N0230 Purity: 98.0%
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β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

For research use only. We do not sell to patients.

CAS No. : 107-95-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
500 mg In-stock
1 g In-stock
2 g In-stock
5 g In-stock
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50 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of β-Alanine:

β-Alanine Related Antibodies

Top Publications Citing Use of Products

    β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23.  [Abstract]

    Western blotting assays revealed that compared with DN mice, DN+β-Alanine (836 mg/kg/day) mice presented decreased AARS1, H3K18la, STAT1, ELOVL5, and ACSL4 levels and increased GPX4 expression in kidney tissues.

    β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23.  [Abstract]

    qPCR assays indicated that compared with DN mice, DN+β-Alanine (836 mg/kg/day) mice presented decreased AARS1, STAT1 and ELOVL5 mRNA expression in kidney tissues.

    β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23.  [Abstract]

    Compared with those in DN model mice, the MDA levels were decreased in the kidneys of DN+β-Alanine (836 mg/kg/day) model mice.

    β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23.  [Abstract]

    Compared with those in DN mice, LPO levels were decreased in the kidneys of DN+β-Alanine (836 mg/kg/day) model mice.

    β-Alanine purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Sep 23.  [Abstract]

    Immunohistochemical staining and transmission electron microscopy (TEM) images of GPX4 in kidney biopsy samples from mice in the control group (Con), β-Alanine group (836 mg/kg/day), diabetic nephropathy (DN) group, and DN+β-alanine group.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO IC50
    209 μM
    Compound: beta-alanine
    Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    		[PMID: 23886812]
    CHO IC50
    41.2 μM
    Compound: beta-alanine
    Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    		[PMID: 23886812]
    CHO IC50
    41.2 μM
    Compound: beta-alanine
    Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    		[PMID: 25147609]
    CHO IC50
    > 100 μM
    Compound: beta-alanine
    Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis
    		[PMID: 25147609]
    In Vitro

    Cells treated with β-alanine display significantly suppressed basal and peak ECAR (aerobic glycolysis), with simultaneous increase in glucose transporter 1 (GLUT1). Additionally, cells treated with β-alanine exhibit significantly reduced basal and peak OCR (oxidative metabolism), which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis. Suppression of glycolytic and oxidative metabolism by β-alanine results in the reduction of total metabolic rate, although cell viability is not affected.β-alanine is shown to reduce both cell migration and proliferation without acting in a cytotoxic fashion. Moreover, β-alanine significantly increases malignant cell sensitivity to doxorubicin, suggesting a potential role as a co-therapeutic agent[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    β-Alanine Related Antibodies
    Clinical Trial
    Molecular Weight

    89.09

    Formula

    C3H7NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (1122.41 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 11.2241 mL 56.1205 mL 112.2410 mL
    5 mM 2.2448 mL 11.2241 mL 22.4482 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (561.21 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (396 KB)

    COA (243 KB) HNMR (139 KB) MS (143 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 11.2241 mL 56.1205 mL 112.2410 mL 280.6025 mL
    5 mM 2.2448 mL 11.2241 mL 22.4482 mL 56.1205 mL
    10 mM 1.1224 mL 5.6121 mL 11.2241 mL 28.0603 mL
    15 mM 0.7483 mL 3.7414 mL 7.4827 mL 18.7068 mL
    20 mM 0.5612 mL 2.8060 mL 5.6121 mL 14.0301 mL
    25 mM 0.4490 mL 2.2448 mL 4.4896 mL 11.2241 mL
    30 mM 0.3741 mL 1.8707 mL 3.7414 mL 9.3534 mL
    40 mM 0.2806 mL 1.4030 mL 2.8060 mL 7.0151 mL
    50 mM 0.2245 mL 1.1224 mL 2.2448 mL 5.6121 mL
    60 mM 0.1871 mL 0.9353 mL 1.8707 mL 4.6767 mL
    80 mM 0.1403 mL 0.7015 mL 1.4030 mL 3.5075 mL
    100 mM 0.1122 mL 0.5612 mL 1.1224 mL 2.8060 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    β-Alanine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    β-Alanine107-95-92-Carboxyethylamine 3-Aminopropanoic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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