1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. L-Tyrosine

L-Tyrosine 

Cat. No.: HY-N0473 Purity: 99.01%
Handling Instructions

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

For research use only. We do not sell to patients.

L-Tyrosine Chemical Structure

L-Tyrosine Chemical Structure

CAS No. : 60-18-4

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Description

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

IC50 & Target

Citrate synthase[1]

In Vitro

Results show that L-Tyrosine in vitro inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM), hippocampus (1.0, 2.0 and 4.0 mM), striatum (4.0 mM) and liver (0.1, 1.0, 2.0 and 4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II–III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0, 2.0 and 4.0 mM) following treatment with L-Tyrosine[1].

In Vivo

The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

1M HCl : 50 mg/mL (275.95 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5191 mL 27.5953 mL 55.1907 mL
5 mM 1.1038 mL 5.5191 mL 11.0381 mL
10 mM 0.5519 mL 2.7595 mL 5.5191 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[1]

Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30°C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, II–III and IV are evaluated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

181.19

Formula

C₉H₁₁NO₃

CAS No.

60-18-4

SMILES

N[[email protected]@H](CC1=CC=C(C=C1)O)C(O)=O

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L-Tyrosine
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L-Tyrosine

Cat. No.: HY-N0473