D-Tyrosine
Based on 1 Customer Validation
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 556-02-5
- Formula: C9H11NO3
- Molecular Weight:181.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tyrosinase[1]
D-Tyrosine (100-500 μM, 48 h) reduces the protein expression levels of tyrosinase, TRP1, and MITF, inhibits α-MSH or UVB-induced melanin synthesis in cells MNT-1 and human primary melanocytes[1].
D-Tyrosine (5 nM-200 μM, 3-24 h) inhibits the bacterial adhesion and biofilm formation in strains Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MNT-1 and human primary melanocytes
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Concentration:100-500 μM
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Incubation Time:48 h
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Result:Inhibited expressions of tyrosinase, TRP1, and MITF.
Chemical Information
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CAS No. 556-02-5
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Appearance Solid
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Molecular Weight 181.19
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Formula C9H11NO3
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Color Off-white to light brown
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SMILES
N[C@H](CC1=CC=C(O)C=C1)C(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
1 M HCl : 25 mg/mL (137.98 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Jisu Park, et al. D-tyrosine Negatively Regulates Melanin Synthesis by Competitively Inhibiting Tyrosinase Activity. Pigment Cell Melanoma Res. 2018 May;31(3):374-383. [Content Brief]
[2]. Cong Yu, et al. Inhibition of Biofilm Formation by D-tyrosine: Effect of Bacterial Type and D-tyrosine Concentration. Water Res. 2016 Apr 1;92:173-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M HCl | 1 mM | 5.5190 mL | 27.5952 mL | 55.1904 mL | 137.9760 mL |
| 5 mM | 1.1038 mL | 5.5190 mL | 11.0381 mL | 27.5952 mL | |
| 10 mM | 0.5519 mL | 2.7595 mL | 5.5190 mL | 13.7976 mL | |
| 15 mM | 0.3679 mL | 1.8397 mL | 3.6794 mL | 9.1984 mL | |
| 20 mM | 0.2760 mL | 1.3798 mL | 2.7595 mL | 6.8988 mL | |
| 25 mM | 0.2208 mL | 1.1038 mL | 2.2076 mL | 5.5190 mL | |
| 30 mM | 0.1840 mL | 0.9198 mL | 1.8397 mL | 4.5992 mL | |
| 40 mM | 0.1380 mL | 0.6899 mL | 1.3798 mL | 3.4494 mL | |
| 50 mM | 0.1104 mL | 0.5519 mL | 1.1038 mL | 2.7595 mL | |
| 60 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2996 mL | |
| 80 mM | 0.0690 mL | 0.3449 mL | 0.6899 mL | 1.7247 mL | |
| 100 mM | 0.0552 mL | 0.2760 mL | 0.5519 mL | 1.3798 mL |
D-Tyrosine Related Classifications
HY-Y0444 Related Classifications
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