1. Metabolic Enzyme/Protease
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Endogenous Metabolite
    GlyT
  3. Sarcosine

Sarcosine (Synonyms: N-Methylglycine; Sarcosin)

Cat. No.: HY-101037 Purity: ≥97.0%
Handling Instructions

Sarcosine (N-Methylglycine; Sarcosin), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor an N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.

For research use only. We do not sell to patients.

Sarcosine Chemical Structure

Sarcosine Chemical Structure

CAS No. : 107-97-1

Size Price Stock Quantity
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sarcosine (N-Methylglycine; Sarcosin), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor an N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Sarcosine (400-800mg/kg; i.p.) significantly raises the threshold for electroconvulsions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino Swiss mice weighing (25-30 g)[2]
Dosage: 100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg
Administration: Intraperitoneal injection
Result: Elevated the seizure threshold at doses of 400 mg/kg and 800 mg/kg in the MEST test in mice.
Clinical Trial
Molecular Weight

89.09

Formula

C₃H₇NO₂

CAS No.

107-97-1

SMILES

O=C(O)CNC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 55 mg/mL (617.35 mM; Need ultrasonic)

DMSO : 1 mg/mL (11.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.2246 mL 56.1230 mL 112.2460 mL
5 mM 2.2449 mL 11.2246 mL 22.4492 mL
10 mM 1.1225 mL 5.6123 mL 11.2246 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥97.0%

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Keywords:

SarcosineN-Methylglycine SarcosinEndogenous MetaboliteGlyTGlycine transportersdepressionschizophreniacognitivedysfunctionInhibitorinhibitorinhibit

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Product Name:
Sarcosine
Cat. No.:
HY-101037
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