2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite GlyT
  4. Sarcosine

Sarcosine  (Synonyms: N-Methylglycine; Sarcosin)

Cat. No.: HY-101037 Purity: ≥98.0%
COA Handling Instructions

Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.

For research use only. We do not sell to patients.

Sarcosine Chemical Structure

Sarcosine Chemical Structure

CAS No. : 107-97-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Solid
100 mg USD 55 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Sarcosine Related Antibodies

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Description

Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

IC50 & Target

GlyT1

 

Human Endogenous Metabolite

 

In Vivo

Sarcosine (400-800mg/kg; i.p.) significantly raises the threshold for electroconvulsions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino Swiss mice weighing (25-30 g)[2]
Dosage: 100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg
Administration: Intraperitoneal injection
Result: Elevated the seizure threshold at doses of 400 mg/kg and 800 mg/kg in the MEST test in mice.
Clinical Trial
Molecular Weight

89.09

Appearance

Solid

Formula

C3H7NO2
CAS No.
SMILES

O=C(O)CNC
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (1122.46 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.2246 mL 56.1230 mL 112.2460 mL
5 mM 2.2449 mL 11.2246 mL 22.4492 mL
10 mM 1.1225 mL 5.6123 mL 11.2246 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (1122.46 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (113 KB)

Handling Instructions (2659 KB)
References
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Sarcosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Sarcosine107-97-1N-Methylglycine SarcosinEndogenous MetaboliteGlyTGlycine transportersdepressionschizophreniacognitivedysfunctionInhibitorinhibitorinhibit

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