1. Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Endogenous Metabolite
    GlyT
  3. Sarcosine-d3

Sarcosine-d3  (Synonyms: N-Methylglycine-d3; Sarcosin-d3)

Cat. No.: HY-101037S1
Handling Instructions

Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

For research use only. We do not sell to patients.

Sarcosine-d<sub>3</sub> Chemical Structure

Sarcosine-d3 Chemical Structure

CAS No. : 118685-91-9

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Description

Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

92.11

Formula

C3H4D3NO2

CAS No.
SMILES

O=C(O)CNC([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (1357.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 10.8566 mL 54.2829 mL 108.5658 mL
5 mM 2.1713 mL 10.8566 mL 21.7132 mL
10 mM 1.0857 mL 5.4283 mL 10.8566 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Sarcosine-d3
Cat. No.:
HY-101037S1
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